Identification of Major Degradation Products of Ketoconazole
AbstractAnalytical methods were developed for the identification of major degradation products of Ketoconazole, an antifungal agent. The stressed degradation of Ketoconazole drug substance was performed under acid, base, thermal, photo and oxidative stress conditions. The major degradation was observed under acid, base and oxidative stress conditions. The degradation study was performed on Inertsil ODS-3V, length 100 X diameter 4.6 mm, particle size 3 μm column using gradient method. These degradants were identified by LC-MS technique.
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MHASKE, R.A.; SAHASRABUDHE, S. Identification of Major Degradation Products of Ketoconazole. Sci. Pharm. 2011, 79, 817-836.
MHASKE RA, SAHASRABUDHE S. Identification of Major Degradation Products of Ketoconazole. Scientia Pharmaceutica. 2011; 79(4):817-836.Chicago/Turabian Style
MHASKE, Rajendra A.; SAHASRABUDHE, Shirish. 2011. "Identification of Major Degradation Products of Ketoconazole." Sci. Pharm. 79, no. 4: 817-836.