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Sci. Pharm. 2011, 79(4), 763-778; doi:10.3797/scipharm.1109-14

A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates

1
Department of Pharmaceutical, Organic and Bioorganic Chemistry, Danylo Halytsky Lviv National Medical University, Pekarska 69, 79010, Lviv, Ukraine
2
Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Science of Ukraine, Murmanska 1, 02094, Kyiv, Ukraine
3
Department of Organic Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland
*
Author to whom correspondence should be addressed.
Received: 19 September 2011 / Accepted: 3 October 2011 / Published: 3 October 2011
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Abstract

The synthesis and evaluation of the anticancer activity of 3’-aryl-5’-arylidene-spiro[3H-indole-3,2’-thiazolidine]-2,4’(1H)-diones and spiro[3H-indole-3,2’-thi-azolidine]-2,4’(1H)-dione-3’-alkanoic acid esters were described. The structure of the compounds was determined by 1H and 13C NMR and their in vitro anticancer activity was tested in the National Cancer Institute. Among the tested compounds, (5'Z)-5'-(benzylidene)-3'-(4-chlorophenyl)spiro[3H-indole-3,2'-thia-zolidine]-2,4'(1H)-dione (IIa) and (5'Z)-3'-(4-chlorophenyl)-5'-[4-(1-methylethyl)-benzylidene]spiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione (IIb) were superior to other related compounds.
Keywords: Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine] Spiro thiazolidinone isatin conjugates; 2,3,5-Trisubstituted 4-thiazolidinones; Anticancer activity; Spiro[indole-3,2'-[1,3]thiazolidine]
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

KAMINSKYY, D.; KHYLUK, D.; VASYLENKO, O.; ZAPRUTKO, L.; LESYK, R. A Facile Synthesis and Anticancer Activity Evaluation of Spiro[Thiazolidinone-Isatin] Conjugates. Sci. Pharm. 2011, 79, 763-778.

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