Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery
AbstractThe aim of the present study was the development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of ketorolac tromethamine (KT), based on methylcellulose (MC) in combination with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature below physiological temperature. HPMC was added to increase viscosity and drug release time. The results indicated a large increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it could be concluded that the developed systems were thus a better alternative to conventional eye drops.
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BHOWMIK, M.; DAS, S.; CHATTOPADHYAY, D.; GHOSH, L.K. Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery. Sci. Pharm. 2011, 79, 351-358.
BHOWMIK M, DAS S, CHATTOPADHYAY D, GHOSH LK. Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery. Scientia Pharmaceutica. 2011; 79(2):351-358.Chicago/Turabian Style
BHOWMIK, Manas; DAS, Sanchita; CHATTOPADHYAY, Dipankar; GHOSH, Lakshmi K. 2011. "Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery." Sci. Pharm. 79, no. 2: 351-358.