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Sci. Pharm. 2011, 79(2), 351-358; doi:10.3797/scipharm.1010-04

Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery

1
Pharmaceutics Research Lab II, Department of Pharmaceutical Technology, Jadavpur University, Kolkata700 032, India
2
Department of Polymer Science & Technology, University College of Science & Technology, 92, A.P.C. Road, University of Calcutta, Kolkata-700 009, India
*
Author to whom correspondence should be addressed.
Received: 14 October 2010 / Accepted: 1 March 2011 / Published: 5 March 2011
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Abstract

The aim of the present study was the development of thermo-sensitive in-situ gels for in-vitro evaluation of ophthalmic delivery systems of ketorolac tromethamine (KT), based on methylcellulose (MC) in combination with hydroxypropylmethyl cellulose (HPMC). The gel temperature of 1% MC solution was observed at 60°C. It was found that 6% oral rehydration salt without dextrose (ORS) was capable to reduce the gel temperature below physiological temperature. HPMC was added to increase viscosity and drug release time. The results indicated a large increase in viscosity at 37°C with addition of HPMC whch provided sustained release of the drug over a 4h period. From in-vitro release studies, it could be concluded that the developed systems were thus a better alternative to conventional eye drops.
Keywords: Methylcellulose; Hydroxypropylmethylcellulose; In-situ gel; ORS Methylcellulose; Hydroxypropylmethylcellulose; In-situ gel; ORS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BHOWMIK, M.; DAS, S.; CHATTOPADHYAY, D.; GHOSH, L.K. Study of Thermo-Sensitive In-Situ Gels for Ocular Delivery. Sci. Pharm. 2011, 79, 351-358.

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