Next Article in Journal
Synthesis and Evaluation of [67Ga]-AMD3100: A Novel Imaging Agent for Targeting the Chemokine Receptor CXCR4
Previous Article in Journal
Scientia Pharmaceutica, Autorenhinweise 2011
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2011, 79(2), 225-238; https://doi.org/10.3797/scipharm.1012-17 (registering DOI)

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

1
Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland
2
Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria CurieSklodowska Square, 20-031 Lublin, Poland
3
Department of Biomedical Science and Technology, University of Cagliari, 09042 Monserrato (CA), Italy
*
Author to whom correspondence should be addressed.
Received: 16 December 2010 / Accepted: 10 February 2011 / Published: 12 February 2011
Download PDF [247 KB, uploaded 26 September 2016]

Abstract

A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
Keywords: Antiviral activity; Cytotoxicity; 3-Phenylpiperidine-2,6-dione; X-ray crystallography Antiviral activity; Cytotoxicity; 3-Phenylpiperidine-2,6-dione; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

BIELENICA, A.; KOSSAKOWSKI, J.; STRUGA, M.; DYBAŁA, I.; LODDO, R.; IBBA, C.; LA COLLA, P. Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones. Sci. Pharm. 2011, 79, 225-238.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top