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Scientia Pharmaceutica, Autorenhinweise 2011
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Sci. Pharm. 2011, 79(2), 225-238; doi:10.3797/scipharm.1012-17 (registering DOI)

Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones

Department of Medical Chemistry, First Faculty of Medicine, The Medical University of Warsaw, 3 Oczki Street, 02-007 Warsaw, Poland
Department of Crystallography, Faculty of Chemistry, Maria Curie-Sklodowska University, 3 Maria CurieSklodowska Square, 20-031 Lublin, Poland
Department of Biomedical Science and Technology, University of Cagliari, 09042 Monserrato (CA), Italy
Author to whom correspondence should be addressed.
Received: 16 December 2010 / Accepted: 10 February 2011 / Published: 12 February 2011
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A set of 13 alkyl derivatives of 3-phenylpiperidine-2,6-dione were synthesized. Newly obtained compounds were investigated in vitro against HIV-1 and other selected viruses. The benzyl 3f and fluorophenyl 3g derivatives showed moderate protection against CVB-2 and the compound 3g also against HSV-1. Derivatives were tested also for their antibacterial and antifungal activity. The molecular structures of 3a and 3d were determined by an X-ray analysis.
Keywords: Antiviral activity; Cytotoxicity; 3-Phenylpiperidine-2,6-dione; X-ray crystallography Antiviral activity; Cytotoxicity; 3-Phenylpiperidine-2,6-dione; X-ray crystallography
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BIELENICA, A.; KOSSAKOWSKI, J.; STRUGA, M.; DYBAŁA, I.; LODDO, R.; IBBA, C.; LA COLLA, P. Synthesis and Biological Evaluation of New 3-Phenyl-1-[(4-arylpiperazin-1-yl)alkyl]- piperidine-2,6-diones. Sci. Pharm. 2011, 79, 225-238.

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