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Sci. Pharm. 2011, 79(1), 113-122; doi:10.3797/scipharm.1012-03

Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form

1
Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. No. 53, Vitthal Udyognagar-388 121, Gujarat, India
2
A. R. College of Pharmacy, P. Box No. 19, Vallabh Vidyanagar-388 120, Gujarat, India
*
Author to whom correspondence should be addressed.
Received: 4 December 2010 / Accepted: 20 January 2011 / Published: 20 January 2011
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Abstract

A simple, specific and stability indicating reversed phase high performance liquid chromatographic method was developed for the simultaneous determination of paracetamol and lornoxicam in tablet dosage form. A Brownlee C-18, 5 μm column having 250×4.6 mm i.d. in isocratic mode, with mobile phase containing 0.05 M potassium dihydrogen phosphate:methanol (40:60, v/v) was used. The flow rate was 1.0 ml/min and effluents were monitored at 266 nm. The retention times of paracetamol and lornoxicam were 2.7 min and 5.1 min, respectively. The linearity for paracetamol and lornoxicam were in the range of 5–200 μg/ml and 0.08–20 μg/ml, respectively. Paracetamol and lornoxicam stock solutions were subjected to acid and alkali hydrolysis, chemical oxidation and dry heat degradation. The proposed method was validated and successfully applied to the estimation of paracetamol and lornoxicam in combined tablet dosage form.
Keywords: RP-HPLC; Validation; Simultaneous determination; Degradation RP-HPLC; Validation; Simultaneous determination; Degradation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SHAH, D.A.; PATEL, N.J.; BALDANIA, S.L.; CHHALOTIYA, U.K.; BHATT, K.K. Stability Indicating LC-Method for Estimation of Paracetamol and Lornoxicam in Combined Dosage Form. Sci. Pharm. 2011, 79, 113-122.

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