Permeability Evaluation Through Chitosan Membranes Using Taguchi Design
AbstractIn the present study, chitosan membranes capable of imitating permeation characteristics of diclofenac diethylamine across animal skin were prepared using cast drying method. The effect of concentration of chitosan, concentration of cross-linking agent (NaTPP), crosslinking time was studied using Taguchi design. Taguchi design ranked concentration of chitosan as the most important factor influencing the permeation parameters of diclofenac diethylamine. The flux of the diclofenac diethylamine solution through optimized chitosan membrane (T9) was found to be comparable to that obtained across rat skin. The mathematical model developed using multilinear regression analysis can be used to formulate chitosan membranes that can mimic the desired permeation characteristics. The developed chitosan membranes can be utilized as a substitute to animal skin for in vitro permeation studies.
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
SHARMA, V.; MARWAHA, R.K.; DUREJA, H. Permeability Evaluation Through Chitosan Membranes Using Taguchi Design. Sci. Pharm. 2010, 78, 977-984.
SHARMA V, MARWAHA RK, DUREJA H. Permeability Evaluation Through Chitosan Membranes Using Taguchi Design. Scientia Pharmaceutica. 2010; 78(4):977-984.Chicago/Turabian Style
SHARMA, Vipin; MARWAHA, Rakesh Kumar; DUREJA, Harish. 2010. "Permeability Evaluation Through Chitosan Membranes Using Taguchi Design." Sci. Pharm. 78, no. 4: 977-984.