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Sci. Pharm. 2010, 78(2), 345-362; doi:10.3797/scipharm.0908-12

Cyclosporine A-Nanosuspension: Formulation, Characterization and In Vivo Comparison with a Marketed Formulation

1
Unison Pharmaceuticals, Ahmedabad, Gujarat, India
2
S. K. Patel college of Pharm Edu & Res, Ganpat University, Gujarat, India
3
Nootan pharmacy college, Visnagar, Gujarat, India
4
TIFAC-CORE in NDDS, The M.S.University of Baroda, India
5
Smt. R. B. Patel Mahila Pharmacy College, Atkot, India
*
Author to whom correspondence should be addressed.
Received: 28 April 2009 / Accepted: 14 April 2010 / Published: 26 April 2010
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Abstract

Cyclosporine A-nanosuspensions were prepared using zirconium oxide beads as a milling media, Poloxamer 407 as a stabilizer and distilled water as an aqueous medium using the Pearl Milling technique. The optimized formulation was characterized in terms of particle size distribution, surface morphology, drug-surfactant interaction, drug content, saturation solubility, osmolarity, and stability. The nanoparticles consisting of Poloxamer-bound cyclosporin A with a mean diameter of 213 nm revealed a spherical shape and 5.69 fold increased saturation solubility as compared to the parent drug. The formulation was found to be iso-osmolar with blood and stable up to 3 months at 2–8°C. In-vivo studies were carried out in albino rats and the pharmacokinetic parameters were compared with a marketed formulation, which indicated better results of the prepared formulation than the marketed one.
Keywords: Cyclosporine A; Nanosuspension; Scanning electron microscopy; Poloxamer; Osmolarity Cyclosporine A; Nanosuspension; Scanning electron microscopy; Poloxamer; Osmolarity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

NAKARANI, M.; PATEL, P.; PATEL, J.; PATEL, P.; MURTHY, R.S.R.; VAGHANI, S.S. Cyclosporine A-Nanosuspension: Formulation, Characterization and In Vivo Comparison with a Marketed Formulation. Sci. Pharm. 2010, 78, 345-362.

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