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Sci. Pharm. 2010, 78(1), 79-92; doi:10.3797/scipharm.0903-16

Evaluation of Ketorolac Tromethamine Microspheres by Chitosan/Gelatin B Complex Coacervation

1
Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700 032, India
2
Department of Pharmaceutics, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist., Karnataka – 571 422, India
3
Department of Pharmacology, Bharathi College of Pharmacy, Bharathi Nagara, Mandya Dist., Karnataka – 571 422, India
*
Author to whom correspondence should be addressed.
Received: 28 March 2009 / Accepted: 17 December 2009 / Published: 19 December 2009
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Abstract

Microspheres (MS) of Ketorolac Tromethamine (KT) for oral delivery were prepared by complex coacervation (method-1) and simple coacervation (method-2) methods without the use of chemical cross–linking agent (glutaraldehyde) to avoid the toxic reactions and other undesirable effects of the chemical cross-linking agents. Alternatively, ionotropic gelation was employed by using sodium-tripolyphosphate (Na-TPP) as cross linking agent. Chitosan and gelatin B were used as polymer and copolymer respectively. All the prepared microspheres were subjected to various physico-chemical studies, such as drug-polymer compatibility by Thin Layer Chromatography (TLC) and Fourier Transform Infra Red Spectroscopy (FTIR), surface morphology by Scanning Electron Microscopy (SEM), frequency distribution, encapsulation efficiency, in-vitro drug release characteristics and release kinetics. The physical state of drug in the microspheres was determined by Differential Scanning Calorimetry (DSC) and X-ray powder Diffractometry (XRD). TLC and FTIR studies indicated no drug-polymer incompatibility. All the MS showed release of drug by a fickian diffusion mechanism. DSC and XRD analysis indicated that the KT trapped in the microspheres existed in an amorphous or disordered-crystalline status in the polymer matrix. It is possible to design a controlled drug delivery system for the prolonged release of KT, improving therapy by possible reduction of time intervals between administrations.
Keywords: Ketorolac tromethamine; Chitosan; Gelatin B; Complex coacervation; Microspheres Ketorolac tromethamine; Chitosan; Gelatin B; Complex coacervation; Microspheres
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BASU, S.K.; KAVITHA, K.; RUPESHKUMAR, M. Evaluation of Ketorolac Tromethamine Microspheres by Chitosan/Gelatin B Complex Coacervation. Sci. Pharm. 2010, 78, 79-92.

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