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Sci. Pharm. 2010, 78(1), 21-32; doi:10.3797/scipharm.0904-16

Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.

1
Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune-411018, India
2
The M. S. University of Baroda, Vadodara-390002, Gujarat, India
*
Author to whom correspondence should be addressed.
Received: 20 April 2009 / Accepted: 4 December 2009 / Published: 6 December 2009
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Abstract

The alkaloidal fraction (AFCP) of roots of Cissampelos pareira Linn. was screened for in-vitro antioxidant activity and immunomodulatory activity in mice. The HPTLC finger print profile was also established for the identification of AFCP which was found to contain 0.176 % of berberine. AFCP possess strong antioxidant activity which was revealed by its ability to scavenge the stable free radical DPPH, superoxide ion and to inhibit lipid peroxidation in rat liver homogenate induced by iron/ADP/Ascorbate complex. AFCP was found to have significant immunosuppressive activity at lower doses (25 and 50 mg/kg) while no activity was observed at higher doses (75 and 100 mg/kg). Humoral antibody titre was significantly (p<0.01) lowered by AFCP at the doses of 25 and 50 mg/kg. Delayed type hypersensitivity response was also significantly (p<0.01) suppressed by the AFCP at the dose of 75 mg/kg. Thus the present study revealed the immunosuppressive and antioxidant activities of the alkaloidal fraction of C. pareira roots.
Keywords: Alkaloidal fraction; Humoral antibody titre; Superoxide; Lipid peroxidation; Cissampelos pareira Linn. Alkaloidal fraction; Humoral antibody titre; Superoxide; Lipid peroxidation; Cissampelos pareira Linn.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BAFNA, A.; MISHRA, S. Antioxidant and Immunomodulatory Activity of the Alkaloidal Fraction of Cissampelos pareira Linn.. Sci. Pharm. 2010, 78, 21-32.

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