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Sci. Pharm. 2009, 77(Short Lectures (SL)), 199; doi:10.3797/scipharm.oephg.21.SL-32 (registering DOI)

Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B

1
Department of Pharmacognosy, University of Vienna, Althanstr. 14, 1090, Vienna, Austria
2
Department of Pharmacognosy, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
3
Department of Pharmaceutical Chemistry, Leopold-Franzens-Universität Innsbruck, Innrain 52c, Josef-Moeller-Haus, 6020, Innsbruck, Austria
*
Author to whom correspondence should be addressed.
Received: 16 April 2009 / Accepted: 16 April 2009 / Published: 16 April 2009
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Abstract

The protein tyrosine phosphatase 1B (PTP1B) is an important negative regulator of the insulin receptor. Elchebly M. et al showed that PTP1B knockout mice enhanced insulin sensitivity and were completely healthy and resistant to weight gain when put on a high fat diet (1). This makes PTP1B a promising target for diabetes type 2 and metabolic syndrome.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BAUMGARTNER, R.R.; STEINDL, T.M.; SCHUSTER, D.; ROLLINGER, J.M.; WOLBER, G.; STUPPNER, H.; ATANASOV, A.G.; HEISS, E.H.; DIRSCH, V.M. Virtual and Real Screening of Natural Products to Find Effective Modulators of Protein Tyrosine Phosphatase PTP1B. Sci. Pharm. 2009, 77, 199.

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