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Sci. Pharm.
Volume 77
Issue 4
10.3797/scipharm.0807-10
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Article

Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage

by
Shyamoshree BASU
1,
Subrata CHAKRABATORTY
2 and
Amal K. BANDYOPADHYAY
1,*
1
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, India
2
Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Dr. Meghnath Saha Sarani, Bidhannagar, Durgapur – 713206, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(4), 899-910; https://doi.org/10.3797/scipharm.0807-10
Submission received: 14 July 2008 / Accepted: 24 September 2009 / Published: 27 September 2009
Versions Notes

Abstract

The aim of the present study was to prepare mucoadhesive nasal gels from mucilage isolated from seeds of Linum usitatissimum L. containing midazolam hydrochloride. Characterization of the isolated mucoadhesive agent was carried out, including determination of pH, swelling property, viscosity and mucoadhesive strength. The results were compared with synthetic polymers (HPMC and carbopol 934). Nasal gels of midazolam were prepared with and without enhancers and the permeation study was carried out using excised goat nasal mucosa. Permeation profiles were evaluated and histological study of nasal mucosae before and after permeation study was also conducted to determine histological change, if any.
Keywords: Nasal • Midazolam hydrochloride • Mucoadhesive • Enhancers Nasal • Midazolam hydrochloride • Mucoadhesive • Enhancers

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MDPI and ACS Style

BASU, S.; CHAKRABATORTY, S.; BANDYOPADHYAY, A.K. Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage. Sci. Pharm. 2009, 77, 899-910. https://doi.org/10.3797/scipharm.0807-10

AMA Style

BASU S, CHAKRABATORTY S, BANDYOPADHYAY AK. Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage. Scientia Pharmaceutica. 2009; 77(4):899-910. https://doi.org/10.3797/scipharm.0807-10

Chicago/Turabian Style

BASU, Shyamoshree, Subrata CHAKRABATORTY, and Amal K. BANDYOPADHYAY. 2009. "Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage" Scientia Pharmaceutica 77, no. 4: 899-910. https://doi.org/10.3797/scipharm.0807-10

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