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Sci. Pharm. 2009, 77(4), 899-910; doi:10.3797/scipharm.0807-10

Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage

1
Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700032, India
2
Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Dr. Meghnath Saha Sarani, Bidhannagar, Durgapur – 713206, India
*
Author to whom correspondence should be addressed.
Received: 14 July 2008 / Accepted: 24 September 2009 / Published: 27 September 2009
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Abstract

The aim of the present study was to prepare mucoadhesive nasal gels from mucilage isolated from seeds of Linum usitatissimum L. containing midazolam hydrochloride. Characterization of the isolated mucoadhesive agent was carried out, including determination of pH, swelling property, viscosity and mucoadhesive strength. The results were compared with synthetic polymers (HPMC and carbopol 934). Nasal gels of midazolam were prepared with and without enhancers and the permeation study was carried out using excised goat nasal mucosa. Permeation profiles were evaluated and histological study of nasal mucosae before and after permeation study was also conducted to determine histological change, if any.
Keywords: Nasal • Midazolam hydrochloride • Mucoadhesive • Enhancers Nasal • Midazolam hydrochloride • Mucoadhesive • Enhancers
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BASU, S.; CHAKRABATORTY, S.; BANDYOPADHYAY, A.K. Development and Evaluation of a Mucoadhesive Nasal Gel of Midazolam Prepared with Linum usitatissimum L. Seed Mucilage. Sci. Pharm. 2009, 77, 899-910.

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