Next Article in Journal
Synthesis of Tetrahydrobenzothieno[ 2,3-d]pyrimidine and Tetrahydrobenzothieno[3,2-e]- [1,2,4]triazolo[4,3-c]pyrimidine Derivatives as Potential Antimicrobial Agents
Previous Article in Journal
Synthesis of [(7-Chloroquinolin-4-yl)amino]chalcones: Potential Antimalarial and Anticancer Agents
Article Menu

Article Versions

Export Article

Open AccessArticle
Sci. Pharm. 2009, 77(4), 743-754; doi:10.3797/scipharm.0906-08

The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells

1
Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-680 Cracow, Poland
2
Department of Microbiology and Immunology, Medical University of Silesia, Jordana 19, 41-808 Zabrze- Rokitnica, Poland
3
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Cracow, Poland
4
Department of Municipal Hygiene, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland
*
Author to whom correspondence should be addressed.
Received: 9 June 2009 / Accepted: 16 October 2009 / Published: 17 October 2009
Download PDF [210 KB, uploaded 21 December 2016]

Abstract

The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2- phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen- 4-yl)acetic acid), and appropriate xanthone derivatives (1–7) was determined. Also the toxicity of the FAA, MFAA ((6-methyl-4-oxo-2-aryl-4H-chromen- 8-yl)acetic acid), XAA and 1–7 against J-774A.1 cultured cells was evaluated. Compound 5 (2-methyl-2-{[(9-oxo-9H-xanthen-2-yl)methyl]sulfanyl}- propanoic acid) was effective in inhibiting chemiluminescence of J-774A.1 cells but most of the other tested compounds stimulated the reaction. FAA and two xanthones with a methoxycarbonyl moeity slightly decreased the generation of nitric oxide at 50 μM. Most of the tested compounds (17) showed weak toxicity at concentration of 100 μM.
Keywords: Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

MARONA, H.; PĘKALA, E.; GUNIA, A.; CZUBA, Z.; SZNELER, E.; SADOWSKI, T.; KRÓL, W. The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells. Sci. Pharm. 2009, 77, 743-754.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top