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Sci. Pharm. 2009, 77(4), 743-754; doi:10.3797/scipharm.0906-08 (registering DOI)

The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells

Department of Technology and Biotechnology of Drugs, Jagiellonian University, Medical College, Medyczna 9, 30-680 Cracow, Poland
Department of Microbiology and Immunology, Medical University of Silesia, Jordana 19, 41-808 Zabrze- Rokitnica, Poland
Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Cracow, Poland
Department of Municipal Hygiene, Medical University of Silesia, Medyków 18, 40-752 Katowice, Poland
Author to whom correspondence should be addressed.
Received: 9 June 2009 / Accepted: 16 October 2009 / Published: 17 October 2009
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The chemiluminescence of stimulated cells with phorbol myristate acetate and the production of nitric oxide after stimulation with lipopolisaccharide in the presence of the parent compounds FAA (flavone-8-acetic acid = (4-oxo-2- phenyl-4H-chromen-8-yl)acetic acid), XAA (xanthone-4-acetic acid = (9-oxo-9Hxanthen- 4-yl)acetic acid), and appropriate xanthone derivatives (1–7) was determined. Also the toxicity of the FAA, MFAA ((6-methyl-4-oxo-2-aryl-4H-chromen- 8-yl)acetic acid), XAA and 1–7 against J-774A.1 cultured cells was evaluated. Compound 5 (2-methyl-2-{[(9-oxo-9H-xanthen-2-yl)methyl]sulfanyl}- propanoic acid) was effective in inhibiting chemiluminescence of J-774A.1 cells but most of the other tested compounds stimulated the reaction. FAA and two xanthones with a methoxycarbonyl moeity slightly decreased the generation of nitric oxide at 50 μM. Most of the tested compounds (17) showed weak toxicity at concentration of 100 μM.
Keywords: Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity Xanthone derivatives; J-774A.1 cells; Chemiluminescence; Toxicity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MARONA, H.; PĘKALA, E.; GUNIA, A.; CZUBA, Z.; SZNELER, E.; SADOWSKI, T.; KRÓL, W. The Influence of some Xanthone Derivatives on the Activity of J-774A.1 Cells. Sci. Pharm. 2009, 77, 743-754.

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