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Sci. Pharm. 2009, 77(3), 617-624; doi:10.3797/scipharm.0812-10

Antipyretic Potential of Swertia chirata Buch Ham. Root Extract

1
Columbia Institute of Pharmacy, Tekari, Raipur, 493111, Chhattisgarh, India
2
Institute of Pharmacy, Pt. Ravishankar Sukla University, Raipur, 493111, Chhattisgarh, India
*
Author to whom correspondence should be addressed.
Received: 18 December 2008 / Accepted: 1 July 2009 / Published: 4 July 2009
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Abstract

The aqueous extract of Swertia chirata Buch Ham. Root (ASC) (Family: Gentianaceae) was evaluated for its antipyretic potential on Brewer’s yeastinduced pyrexia in albino rats and Typhoid-Paratyphoid A, B vaccine induced Hyperexia in rabbits. In both models, the extract, at dose of 200 mg kg−1 body wt. and 400 mg kg−1 body weight, produced significant (p<0.001) reduction in elevated body temperature in a dose dependent manner. The antipyretic effect of the extract was comparable to that of paracetamol (150 mg kg−1 body weight, p.o.), a standard antipyretic agent.
Keywords: Swertia chirata; Chirayta; Antipyretic; Hyperexia; Fever Swertia chirata; Chirayta; Antipyretic; Hyperexia; Fever
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

BHARGAVA, S.; RAO, P.S.; BHARGAVA, P.; SHUKLA, S. Antipyretic Potential of Swertia chirata Buch Ham. Root Extract. Sci. Pharm. 2009, 77, 617-624.

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