Next Article in Journal
Evaluation of the Anabolic, Aphrodisiac and Reproductive Activity of Anacyclus Pyrethrum DC in Male Rats
Previous Article in Journal
Rapid HPLC Analysis for Quantitative Determination of the Two Isomeric Triterpenic Acids, Oleanolic acid and Ursolic acid, in Plantago Major
Article Menu

Article Versions

Export Article

Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle
Sci. Pharm. 2009, 77(1), 87-96; https://doi.org/10.3797/scipharm.0803-15 (registering DOI)

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities

1
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
2
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
3
Process and Product Development (Industrial Technology Centre), Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
*
Author to whom correspondence should be addressed.
Received: 19 March 2008 / Accepted: 7 January 2009 / Published: 8 January 2009
Download PDF [198 KB, uploaded 20 December 2016]

Abstract

Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among these strains, A. flavus was the only microorganism capable of transforming artemisinin to deoxyartemisinin in higher yields than the previous reports. The structure of deoxyartemisinin was elucidated by spectroscopy. Deoxyartemisinin showed antibacterial activity against Staphylococcus aureus, S. epidermidis and S. mutans at a minimum inhibitory concentration (MIC) of 1 mg/mL compared to artemisinin whose MIC was >2 mg/mL.
Keywords: Biotransformation; Artemisinin; Deoxyartemisinin; Aspergillus flavus; Antibacterial Biotransformation; Artemisinin; Deoxyartemisinin; Aspergillus flavus; Antibacterial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

SRIVASTAVA, S.; LUQMAN, S.; FATIMA, A.; DAROKAR, M.P.; NEGI, A.S.; KUMAR, J.K.; SHANKER, K.; CHANOTIYA, C.S.; TANDON, S.; KHANUJA, S.P.S. Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities. Sci. Pharm. 2009, 77, 87-96.

Show more citation formats Show less citations formats

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Sci. Pharm. EISSN 2218-0532 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top