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Sci. Pharm. 2009, 77(1), 87-96; doi:10.3797/scipharm.0803-15

Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities

1
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
2
Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
3
Process and Product Development (Industrial Technology Centre), Central Institute of Medicinal and Aromatic Plants (Council of Scientific and Industrial Research), Lucknow–226015, India
*
Author to whom correspondence should be addressed.
Received: 19 March 2008 / Accepted: 7 January 2009 / Published: 8 January 2009
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Abstract

Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Several fungal strains Saccharomyces cerevisiae, Aspergillus flavus, Aspergillus niger and Picchia pastoris were used to biotransform artemisinin. Among these strains, A. flavus was the only microorganism capable of transforming artemisinin to deoxyartemisinin in higher yields than the previous reports. The structure of deoxyartemisinin was elucidated by spectroscopy. Deoxyartemisinin showed antibacterial activity against Staphylococcus aureus, S. epidermidis and S. mutans at a minimum inhibitory concentration (MIC) of 1 mg/mL compared to artemisinin whose MIC was >2 mg/mL.
Keywords: Biotransformation; Artemisinin; Deoxyartemisinin; Aspergillus flavus; Antibacterial Biotransformation; Artemisinin; Deoxyartemisinin; Aspergillus flavus; Antibacterial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

SRIVASTAVA, S.; LUQMAN, S.; FATIMA, A.; DAROKAR, M.P.; NEGI, A.S.; KUMAR, J.K.; SHANKER, K.; CHANOTIYA, C.S.; TANDON, S.; KHANUJA, S.P.S. Biotransformation of Artemisinin Mediated through Fungal Strains for Obtaining Derivatives with Novel Activities. Sci. Pharm. 2009, 77, 87-96.

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