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Sci. Pharm. 2008, 76(3), 533-540; doi:10.3797/scipharm.0807-24 (registering DOI)

Preservative Evaluation of Caprylic Acid Derivatives in Aluminium Hydroxide Gel – USP

1
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar-125001, India
2
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak-124001, India
*
Author to whom correspondence should be addressed.
Received: 30 July 2008 / Accepted: 1 September 2008 / Published: 2 September 2008
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Abstract

The potential derivatives of caprylic acid were subjected to preservative efficacy testing in Aluminium Hydroxide Gel – USP using Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, and Escherichia coli MTCC 1652 as representative challenging microorganisms for antimicrobial effectiveness testing as per USP 2004. The caprylic acid derivative, capryl hydrazide exhibited better preservative efficacy than caprylic acid as well as the standard preservatives, methyl paraben and propyl paraben.
Keywords: Caprylic acid; Capryl hydrazide; p-Chlorocaprylanilide; Preservative efficacy Caprylic acid; Capryl hydrazide; p-Chlorocaprylanilide; Preservative efficacy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

CHAUDHARY, J.; RAJPAL, A.K.; JUDGE, V.; NARANG, R.; NARASIMHAN, B. Preservative Evaluation of Caprylic Acid Derivatives in Aluminium Hydroxide Gel – USP. Sci. Pharm. 2008, 76, 533-540.

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