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Sci. Pharm. 2008, 76(3), 451-470; doi:10.3797/scipharm.0805-03 (registering DOI)

Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L.

Department of Pharmaceutical Sciences, University of Trieste, P.zle Europa, 1, 34127 Trieste, Italy
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Author to whom correspondence should be addressed.
Received: 6 May 2008 / Accepted: 3 September 2008 / Published: 5 September 2008
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Abstract

A new cerebroside (1), together with three known ones (2–4) have been isolated from the whole plants of Euphorbia platyphyllos L. The structures were established by FT-IR spectroscopy, FAB-MS, advanced two-dimensional NMR, including 1H-NMR, 1H,1H-COSY, HMQC and HMBC experiments and chemical reactions. The structures of the cerebrosides were characterized as 1-O-β-D-glycosides of phytosphingosines, which comprised a common long-chain base, (2S,3S,4R,8Z)-2-aminooctadec-8-ene-1,3,4-triol (1–3) and (2S,3S,4E,8E)-2-aminooctadeca-4,8-diene-1,3-diol (4) with 2-hydroxy fatty acids of varying chain lengths (C16, C24, C26:1, C28:1) linked to the amino group. The isolated compounds have been evaluated for their antifungal and antitubercular activities.
Keywords: Euphorbia platyphyllos L.; Cerebrosides; Phytosphingosines; 2-Hydroxy-fatty acids Euphorbia platyphyllos L.; Cerebrosides; Phytosphingosines; 2-Hydroxy-fatty acids
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

CATENI, F.; ZILIC, J.; ZACCHIGNA, M. Isolation and Structure Elucidation of Cerebrosides from Euphorbia Platyphyllos L.. Sci. Pharm. 2008, 76, 451-470.

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