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Sci. Pharm. 2008, 76(2), 171-184; doi:10.3797/scipharm.0803-21 (registering DOI)

Tirofiban Preserves Endothelial Junctions and Decreases Endothelin-1

Department of Cardiology, Cardiovascular Institute and Fu-Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
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Author to whom correspondence should be addressed.
Received: 22 March 2008 / Accepted: 6 May 2008 / Published: 11 May 2008
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Abstract

It has been verified that glycoprotein IIb/IIIa inhibitor tirofiban can attenuate myocardial no-reflow. Myocardial no-reflow has been associated with alterations in endothelial junctions. In addition, ET-1 is an important mechanism for myocardial no-reflow. However, the effect of tirofiban on endothelial junctions and Endothelin-1 (ET-1) is unknown. Methods: Twenty-eight mini-swines were randomized into 3 study groups: 10 in control, 10 given an intravenous infusion of tirofiban and 8 in sham-operated. Acute myocardial infarction and reperfusion model was created with three-hour occlusion of the left anterior descending coronary artery followed by one-hour reperfusion. Results: In control group, plasma ET-1 significantly increased, ET-1 or VE-cadherin level in the reflow and no-reflow myocardium was significantly higher or lower than that in normal myocardium. Compared with the control group, tirofiban significantly decreased plasma ET-1 and myocardial tissue ET-1, maintained VE-cadherin level. Conclusions: Tirofiban is effective in preserving endothelial junction. This beneficial effect of tirofiban could be partly due to its reduction of ET-1.
Keywords: Acute myocardial infarction; Endothelin-1; Reperfusion; Tirofiban; No-reflow Acute myocardial infarction; Endothelin-1; Reperfusion; Tirofiban; No-reflow
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

ZHAO, J.-L.; YANG, Y.-J.; PEI, W.-D.; SUN, Y.-H.; ZHAI, M.; LIU, Y.-X.; GAO, R.-L. Tirofiban Preserves Endothelial Junctions and Decreases Endothelin-1. Sci. Pharm. 2008, 76, 171-184.

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