In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470, Eskişehir, Turkey
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Author to whom correspondence should be addressed.
Sci. Pharm. 2005, 73(1), 59-74; https://doi.org/10.3797/scipharm.aut-05-05
Submission received: 20 February 2004
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Accepted: 1 December 2005
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Published: 30 March 2005
Abstract
Sustained release matrix tablets of clarithromycin were prepared using different polymers as Hydroxypropyl methylcellulose (H PMC), Carbopol 934 and Eudragit RL/PO by direct compression technique. For the quality control of these formulations, weight deviation, hardness, friability, diameter-height ratio, content uniformity of the active substance and in vitro dissolution technique were performed. HPLC was used for the assay of clarithromycin and the assay method was validated. Dissolution profiles of the tablets were plotted and evaluated kinetically. The effects on drug release of polymer type and concentrations were investigated by 23 factorial design. The tablets containing HPMC, Carbopol 934 and Eudragit RLIPO were found suitably to sustain drug release
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MDPI and ACS Style
Genç, L.; Kıran, A.M. In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin. Sci. Pharm. 2005, 73, 59-74. https://doi.org/10.3797/scipharm.aut-05-05
AMA Style
Genç L, Kıran AM. In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin. Scientia Pharmaceutica. 2005; 73(1):59-74. https://doi.org/10.3797/scipharm.aut-05-05
Chicago/Turabian StyleGenç, Lütfi, and A. Muhittin Kıran. 2005. "In Vitro Evaluation of Sustained Released Matrix Tablet Formulations of Clarithromvcin" Scientia Pharmaceutica 73, no. 1: 59-74. https://doi.org/10.3797/scipharm.aut-05-05
