Synthesis of Tetrahydro-2H-[1,3,5]thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity
Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani 333031, India
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Author to whom correspondence should be addressed.
Sci. Pharm. 2004, 72(1), 35-41; https://doi.org/10.3797/scipharm.aut-04-04
Submission received: 8 April 2003
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Revised: 11 November 2003
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Accepted: 11 November 2003
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Published: 9 March 2004
Abstract
3-Substituted-5-(4-pyridylcarboxamide)tetrahydro-2H-[1,3,5]thiadizine-2-thione derivatives (1-9) were synthesized as derivatives of isoniazid (INH) to overcome the resistance developed with its therapeutic use. The structures were confirmed by their spectral and elemental analyses data. These derivatives revealed higher lipophilicity compared with INH. The antimycobacterial activity of the synthesized compounds and INH was evaluated in vitro against Mycobacterium tuberculosis H37Rv at 6.25 µg/ml in BACTEC 12B medium using the BACTEC 460 radiometric system. The derivatives exhibited antitubercular activity.
Keywords:
Isoniazid; Antitubercular
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MDPI and ACS Style
Sriram, D.; Jyothi Mallika, K.; Yogeeswari, P. Synthesis of Tetrahydro-2H-[1,3,5]thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity. Sci. Pharm. 2004, 72, 35-41. https://doi.org/10.3797/scipharm.aut-04-04
AMA Style
Sriram D, Jyothi Mallika K, Yogeeswari P. Synthesis of Tetrahydro-2H-[1,3,5]thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity. Scientia Pharmaceutica. 2004; 72(1):35-41. https://doi.org/10.3797/scipharm.aut-04-04
Chicago/Turabian StyleSriram, D., K. Jyothi Mallika, and P. Yogeeswari. 2004. "Synthesis of Tetrahydro-2H-[1,3,5]thiadiazine-5-(4-pyridylcarboxamido)-2-thione with antitubercular activity" Scientia Pharmaceutica 72, no. 1: 35-41. https://doi.org/10.3797/scipharm.aut-04-04
