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Diseases 2018, 6(1), 19; https://doi.org/10.3390/diseases6010019

Hyper-Uricemia and Gouty Access in the Adult Population of the Southeast of Gabon: Biochemical Aspects

1
Laboratory of Research in Biochemistry (LAREBIO), University of Sciences and Technology of Masuku, Franceville P.O. Box 943, Gabon
2
International Medical Research Center of Franceville (CIRMF), Franceville P.O. Box 769, Gabon
3
Ministry of Public Health of Gabon, Libreville BP 50, Gabon
*
Author to whom correspondence should be addressed.
Received: 26 December 2017 / Revised: 4 February 2018 / Accepted: 6 February 2018 / Published: 8 March 2018
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Abstract

Gout is caused by a chronic hyperuricemia whose complications are not currently well evaluated in Africa. The aim of this study was to determine the prevalence and risk factors of hyperuricemia and gout in 85 patients recruited. A total of 26 cases of hyperuricemia, i.e., 30.6% of the study population, with 12 cases of gout and seven cases of gouty access. In this population, hyperuricemia was proportional to age (p-value < 10−4, OR = 2.6), but it was more prevalent in men, 23.5% versus 7.1% for women (p-value = 0.0047). In addition, none of these women showed signs of a gouty affection. Consumption of alcohol (OR = 13) and nucleoprotein-rich foods, obesity (BMI 30 kg/m2; OR = 6), family history of gout (OR = 6.8), as well as diseases such as high blood pressure (associated with taking diuretics; OR = 1.7), renal insufficiency (OR = 4.4) and diabetes (p < 0.049) were the main factors of the diseases associated with gout and hyperuricemia in this population. The biochemical role of these factors may increase and/or decrease the processes of synthesis and/or elimination of uric acid by acting on metabolites involved in the regulation of urate production. View Full-Text
Keywords: uric acid; hyperuricemia; gout access; metabolism; risk factor uric acid; hyperuricemia; gout access; metabolism; risk factor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Ndong Atome, G.R.; Ngoua Meye Misso, R.-L.; Sima Obiang, C.; Onanga, R.; Nkogue Mba, D. Hyper-Uricemia and Gouty Access in the Adult Population of the Southeast of Gabon: Biochemical Aspects. Diseases 2018, 6, 19.

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