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Systems 2014, 2(2), 237-242; doi:10.3390/systems2020237
Communication

Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology

Received: 29 April 2014; in revised form: 21 May 2014 / Accepted: 28 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Towards a Second Generation General System Theory)
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Abstract: The methodologies advocated in computational biology are in many cases proper system-level approaches. These methodologies are variously connected to the notion of “mesosystem” and thus on the focus on relational structures that are at the basis of biological regulation. Here, I describe how the formalization of biological systems by means of graph theory constitutes an extremely fruitful approach to biology. I suggest the epistemological relevance of the notion of graph resides in its multilevel character allowing for a natural “middle-out” causation making largely obsolete the traditional opposition between “top-down” and “bottom-up” styles of reasoning, so fulfilling the foundation dream of systems science of a direct link between systems analysis and the underlying physical reality.
Keywords: bioinformatics; graph theory; chemistry; molecular biology; systems analysis bioinformatics; graph theory; chemistry; molecular biology; systems analysis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Giuliani, A. Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology. Systems 2014, 2, 237-242.

AMA Style

Giuliani A. Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology. Systems. 2014; 2(2):237-242.

Chicago/Turabian Style

Giuliani, Alessandro. 2014. "Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology." Systems 2, no. 2: 237-242.


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