Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology
AbstractThe methodologies advocated in computational biology are in many cases proper system-level approaches. These methodologies are variously connected to the notion of “mesosystem” and thus on the focus on relational structures that are at the basis of biological regulation. Here, I describe how the formalization of biological systems by means of graph theory constitutes an extremely fruitful approach to biology. I suggest the epistemological relevance of the notion of graph resides in its multilevel character allowing for a natural “middle-out” causation making largely obsolete the traditional opposition between “top-down” and “bottom-up” styles of reasoning, so fulfilling the foundation dream of systems science of a direct link between systems analysis and the underlying physical reality. View Full-Text
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Giuliani, A. Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology. Systems 2014, 2, 237-242.
Giuliani A. Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology. Systems. 2014; 2(2):237-242.Chicago/Turabian Style
Giuliani, Alessandro. 2014. "Networks as a Privileged Way to Develop Mesoscopic Level Approaches in Systems Biology." Systems 2, no. 2: 237-242.