Next Article in Journal
Rai1 Haploinsufficiency Is Associated with Social Abnormalities in Mice
Previous Article in Journal
Identification of Highly Specific scFvs against Total Adiponectin for Diagnostic Purposes
Article Menu

Export Article

Open AccessReview
Biology 2017, 6(2), 27; doi:10.3390/biology6020027

Is Polysialylated NCAM Not Only a Regulator during Brain Development But also during the Formation of Other Organs?

1
Department of Reproductive Biology, Leibniz Institute for Farm Animal Biology (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany
2
ITech Progress GmbH, Donnersbergweg 4, 67059 Ludwigshafen, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Jukka Finne
Received: 1 March 2017 / Revised: 24 April 2017 / Accepted: 24 April 2017 / Published: 27 April 2017
View Full-Text   |   Download PDF [2700 KB, uploaded 27 April 2017]   |  

Abstract

In mammals several cell adhesion molecules are involved during the pre- and postnatal development of all organ systems. A very prominent member of this family is the neural cell adhesion molecule (NCAM). Interestingly, NCAM can be a target for a special form of posttranslational modification: polysialylation. Whereas nearly all extracellular proteins bear mono-sialic acid residues, only a very small group can be polysialylated. Polysialic acid is a highly negatively-charged sugar polymer and can comprise more than 90 sialic acid residues in postnatal mouse brains increasing dramatically the hydrodynamic radius of their carriers. Thus, adhesion and communication processes on cell surfaces are strongly influenced allowing, e.g., the migration of neuronal progenitor cells. In the developing brain the essential role of polysialylated NCAM has been demonstrated in many studies. In comparison to the neuronal system, however, during the formation of other organs the impact of the polysialylated form of NCAM is not well characterized and the number of studies is limited so far. This review summarizes these observations and discusses possible roles of polysialylated NCAM during the development of organs other than the brain. View Full-Text
Keywords: polysialic acid; NCAM; sialic acids; cell adhesion molecule; organogenesis; pre- and postnatal development polysialic acid; NCAM; sialic acids; cell adhesion molecule; organogenesis; pre- and postnatal development
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Galuska, C.E.; Lütteke, T.; Galuska, S.P. Is Polysialylated NCAM Not Only a Regulator during Brain Development But also during the Formation of Other Organs? Biology 2017, 6, 27.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top