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Biology 2016, 5(4), 54; doi:10.3390/biology5040054

Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors

Department of Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso 86100, Italy
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Academic Editor: Chris O′Callaghan
Received: 30 September 2016 / Revised: 14 November 2016 / Accepted: 5 December 2016 / Published: 14 December 2016
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Abstract

Testicular germ cell tumors (TGCTs) derive from primordial germ cells. Their maturation is blocked at different stages, reflecting histological tumor subtypes. A common genetic alteration in TGCT is a deletion of the chromosome 1 short arm, where the PRDM2 gene, belonging to the Positive Regulatory domain gene (PRDM) family, is located. Expression of PRDM2 gene is shifted in different human tumors, where the expression of the two principal protein forms coded by PRDM2 gene, RIZ1 and RIZ2, is frequently unbalanced. Therefore, PRDM2 is actually considered a candidate tumor suppressor gene in different types of cancer. Although recent studies have demonstrated that PRDM gene family members have a pivotal role during the early stages of testicular development, no information are actually available on the involvement of these genes in TGCTs. In this article we show by qRT-PCR analysis that PRDM2 expression level is modulated by proliferation and differentiation agents such as estradiol, whose exposure during fetal life is probably an important risk factor for TGCTs development in adulthood. Furthermore in normal and cancer germ cell lines, PRDM2 binds estradiol receptor α (ERα) and influences proliferation, survival and apoptosis, as previously reported using MCF-7 breast cancer cell line, suggesting a potential tumor-suppressor role in TGCT formation. View Full-Text
Keywords: PRDM gene family; RIZ1; cancer; testicular germ cell tumors; cell proliferation PRDM gene family; RIZ1; cancer; testicular germ cell tumors; cell proliferation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Di Zazzo, E.; Porcile, C.; Bartollino, S.; Moncharmont, B. Critical Function of PRDM2 in the Neoplastic Growth of Testicular Germ Cell Tumors. Biology 2016, 5, 54.

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