Next Article in Journal
Fish Immunoglobulins
Next Article in Special Issue
Anaphase B
Previous Article in Journal
Use of a Fluorescent Aptamer RNA as an Exonic Sequence to Analyze Self-Splicing Ability of a Group I Intron from Structured RNAs
Article Menu

Export Article

Open AccessReview
Biology 2016, 5(4), 44; doi:10.3390/biology5040044

A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint

Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Academic Editor: J. Richard McIntosh
Received: 4 October 2016 / Revised: 10 November 2016 / Accepted: 14 November 2016 / Published: 19 November 2016
(This article belongs to the Special Issue Mechanisms of Mitotic Chromosome Segregation)
View Full-Text   |   Download PDF [951 KB, uploaded 19 November 2016]   |  

Abstract

The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures accurate chromosome segregation during cell division. It consists of a mechanochemical signal transduction mechanism that senses the attachment of chromosomes to the spindle, and a signaling cascade that inhibits cell division if one or more chromosomes are not attached. Extensive investigations of both these component systems of the SAC have synthesized a comprehensive understanding of the underlying molecular mechanisms. This review recounts the milestone results that elucidated the SAC, compiles a simple model of the complex molecular machinery underlying the SAC, and highlights poorly understood facets of the biochemical design and cell biological operation of the SAC that will drive research forward in the near future. View Full-Text
Keywords: mitosis; spindle assembly checkpoint; signal transduction; aneuploidy mitosis; spindle assembly checkpoint; signal transduction; aneuploidy
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Joglekar, A.P. A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint. Biology 2016, 5, 44.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Biology EISSN 2079-7737 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top