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Biology 2016, 5(1), 5; doi:10.3390/biology5010005

Notch-Mediated Cell Adhesion

Department of Molecular and Cellular Biology, Division of Immunology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, Tottori 683-8503, Japan
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Academic Editor: Chris O’Callaghan
Received: 26 October 2015 / Revised: 12 January 2016 / Accepted: 13 January 2016 / Published: 16 January 2016
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Abstract

Notch family members are generally recognized as signaling molecules that control various cellular responses in metazoan organisms. Early fly studies and our mammalian studies demonstrated that Notch family members are also cell adhesion molecules; however, information on the physiological roles of this function and its origin is limited. In this review, we discuss the potential present and ancestral roles of Notch-mediated cell adhesion in order to explore its origin and the initial roles of Notch family members dating back to metazoan evolution. We hypothesize that Notch family members may have initially emerged as cell adhesion molecules in order to mediate multicellularity in the last common ancestor of metazoan organisms. View Full-Text
Keywords: Notch; Delta/Delta-like; Serrate/Jagged; cell adhesion; metazoan evolution Notch; Delta/Delta-like; Serrate/Jagged; cell adhesion; metazoan evolution
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Murata, A.; Hayashi, S.-I. Notch-Mediated Cell Adhesion. Biology 2016, 5, 5.

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