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Biology 2015, 4(3), 540-555; doi:10.3390/biology4030540

Multi-Facial, Non-Peptidic α-Helix Mimetics

1
Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine St., Baltimore, MD 21201, USA
2
University of Maryland Greenebaum Cancer Center, 22 S. Greene St., Baltimore, MD 21201, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Chris O'Callaghan
Received: 21 July 2015 / Revised: 11 August 2015 / Accepted: 14 August 2015 / Published: 31 August 2015
View Full-Text   |   Download PDF [924 KB, uploaded 31 August 2015]   |  

Abstract

α-Helices often recognize their target proteins at protein–protein interfaces through more than one recognition face. This review describes the state-of-the-art in the design of non-peptidic α-helix mimetics that reproduce functionality from multiple faces of an α-helix. View Full-Text
Keywords: α-helix mimetic; protein–protein interaction; proteomimetic; amphipathic; cancer; Bcl-2; HMD2; Bak; Bim; p53 α-helix mimetic; protein–protein interaction; proteomimetic; amphipathic; cancer; Bcl-2; HMD2; Bak; Bim; p53
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lanning, M.E.; Fletcher, S. Multi-Facial, Non-Peptidic α-Helix Mimetics. Biology 2015, 4, 540-555.

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