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DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals
Department of Bioresource and Environmental Sciences, Kyoto Sangyo University, Kamigamo-Motoyama, Kitaku, Kyoto 603-8555, Japan
Research Institute for Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan
* Authors to whom correspondence should be addressed.
Received: 12 September 2013; in revised form: 8 November 2013 / Accepted: 12 November 2013 / Published: 21 November 2013
Abstract: The genome of an organism is under constant attack from endogenous and exogenous DNA damaging factors, such as reactive radicals, radiation, and genotoxins. Therefore, DNA damage response systems to sense DNA damage, arrest cell cycle, repair DNA lesions, and/or induce programmed cell death are crucial for maintenance of genomic integrity and survival of the organism. Genome sequences revealed that, although plants possess many of the DNA damage response factors that are present in the animal systems, they are missing some of the important regulators, such as the p53 tumor suppressor. These observations suggest differences in the DNA damage response mechanisms between plants and animals. In this review the DNA damage responses in plants and animals are compared and contrasted. In addition, the function of SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a plant-specific transcription factor that governs the robust response to DNA damage, is discussed.
Keywords: DNA damage response; genome stability; signaling; Arabidopsis; SOG1; p53
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Yoshiyama, K.O.; Sakaguchi, K.; Kimura, S. DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals. Biology 2013, 2, 1338-1356.
Yoshiyama KO, Sakaguchi K, Kimura S. DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals. Biology. 2013; 2(4):1338-1356.
Yoshiyama, Kaoru O.; Sakaguchi, Kengo; Kimura, Seisuke. 2013. "DNA Damage Response in Plants: Conserved and Variable Response Compared to Animals." Biology 2, no. 4: 1338-1356.