A Review of Contact Lens-Induced Limbal Stem Cell Deficiency
Abstract
:Simple Summary
Abstract
1. Introduction
2. Epidemiology
3. Pathophysiology
- Lens diameter, blinking;
- Volume and rate at which tears are produced/secreted;
- CL properties: lens-to-cornea fitting relationship, material composition, design (base curve/diameter combination, zone size, etc.).
4. Risk Factors
4.1. Contact Lens Properties
4.2. Factors Causing Dry Eye
4.3. Concomitant Ocular Disease
5. Diagnosis
5.1. Histologic Markers
5.2. Impression Cytology
5.3. In Vivo Confocal Microscopy
5.4. AS-OCT
5.5. OCT-Angiography (OCT-A)
6. Management
6.1. Conservative Management
6.2. Surgical Management
6.2.1. Superficial Keratectomy (SK)
6.2.2. Phototherapeutic Keratectomy (PTK)
6.2.3. Penetrating Keratoplasty (PK)
6.2.4. Amniotic Membrane Transplantation (AMT)
6.2.5. Autologous Limbal Stem Cell Transplantation
6.2.6. Narrow Strip Conjunctival Autograft
6.2.7. Simple Limbal Epithelial Transplantation (SLET)
6.2.8. Living-Related Conjunctival Limbal Allograft (Lr-CLAL)
6.2.9. Cadaver Donor Keratolimbal Allograft (Cd-KLAL)
6.2.10. Cultivated Limbal Epithelial Transplantation (CLET)
7. Current Gaps
8. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Congenital |
|
Traumatic/acquired |
|
Autoimmune |
|
Idiopathic |
Early | Fluorescein staining in a punctate pattern in a curve-like distribution: |
Late | Punctate staining merges into a linear pattern.Eventually progresses into a centrally distributed confluent sheet [10,37]. |
Later-stage | Corneal pannus, which loosely refers to [10,28]:
|
End-stage | Signs include [71,72]:
|
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Lee, Y.F.; Yong, D.W.W.; Manotosh, R. A Review of Contact Lens-Induced Limbal Stem Cell Deficiency. Biology 2023, 12, 1490. https://doi.org/10.3390/biology12121490
Lee YF, Yong DWW, Manotosh R. A Review of Contact Lens-Induced Limbal Stem Cell Deficiency. Biology. 2023; 12(12):1490. https://doi.org/10.3390/biology12121490
Chicago/Turabian StyleLee, Yhu Fhei, Dayna Wei Wei Yong, and Ray Manotosh. 2023. "A Review of Contact Lens-Induced Limbal Stem Cell Deficiency" Biology 12, no. 12: 1490. https://doi.org/10.3390/biology12121490