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Antibiotics 2015, 4(2), 136-159; doi:10.3390/antibiotics4020136

Host Defense Peptides from Asian Frogs as Potential Clinical Therapies

1
Molecular Ecology Lab, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala 695014, India
2
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Yerkes National Primate Research Center, 954 Gatewood Rd, Atlanta, GA 30329, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: William M. Shafer
Received: 10 November 2014 / Revised: 28 February 2015 / Accepted: 4 March 2015 / Published: 30 March 2015
(This article belongs to the Special Issue Antimicrobial Peptides)
View Full-Text   |   Download PDF [1806 KB, uploaded 30 March 2015]   |  

Abstract

Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological membranes, and their peculiar mode of action. Even though HDPs from 60 Asian frog species belonging to 15 genera have been characterized, research into these peptides is at a very early stage. The purpose of this review is to showcase the status of peptide research in Asia. Here we provide a summary of HDPs from Asian frogs. View Full-Text
Keywords: Host defense peptides; Asian frog; Multi-drug resistance; Anti-microbial peptides Host defense peptides; Asian frog; Multi-drug resistance; Anti-microbial peptides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kumar, V.T.; Holthausen, D.; Jacob, J.; George, S. Host Defense Peptides from Asian Frogs as Potential Clinical Therapies. Antibiotics 2015, 4, 136-159.

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