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Biosensors 2017, 7(1), 7; doi:10.3390/bios7010007

Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers

1
Department of Physics University of Nebraska at Omaha 6001 Dodge Street, Omaha, NE 68182, USA
2
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Torsten Frosch
Received: 6 December 2016 / Revised: 2 January 2017 / Accepted: 3 January 2017 / Published: 12 January 2017
(This article belongs to the Collection Raman and IR Spectroscopic Sensing)
View Full-Text   |   Download PDF [2020 KB, uploaded 12 January 2017]   |  

Abstract

Detection of biomarkers is of vital importance in disease detection, management, and monitoring of therapeutic efficacy. Extensive efforts have been devoted to the development of novel diagnostic methods that detect and quantify biomarkers with higher sensitivity and reliability, contributing to better disease diagnosis and prognosis. When it comes to such devastating diseases as cancer, these novel powerful methods allow for disease staging as well as detection of cancer at very early stages. Over the past decade, there have been some advances in the development of platforms for biomarker detection of diseases. The main focus has recently shifted to the development of simple and reliable diagnostic tests that are inexpensive, accurate, and can follow a patient’s disease progression and therapy response. The individualized approach in biomarker detection has been also emphasized with detection of multiple biomarkers in body fluids such as blood and urine. This review article covers the developments in Surface-Enhanced Raman Scattering (SERS) and related technologies with the primary focus on immunoassays. Limitations and advantages of the SERS-based immunoassay platform are discussed. The article thoroughly describes all components of the SERS immunoassay and highlights the superior capabilities of SERS readout strategy such as high sensitivity and simultaneous detection of a multitude of biomarkers. Finally, it introduces recently developed strategies for in vivo biomarker detection using SERS. View Full-Text
Keywords: Surface-Enhanced Raman Scattering; biomarkers; nanodiagnostics; immunoassay Surface-Enhanced Raman Scattering; biomarkers; nanodiagnostics; immunoassay
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Smolsky, J.; Kaur, S.; Hayashi, C.; Batra, S.K.; Krasnoslobodtsev, A.V. Surface-Enhanced Raman Scattering-Based Immunoassay Technologies for Detection of Disease Biomarkers. Biosensors 2017, 7, 7.

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