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Biosensors 2016, 6(3), 28; doi:10.3390/bios6030028

Aptasensors Based on Whispering Gallery Mode Resonators

Istituto di Fisica Applicata Nello Carrara (IFAC CNR), Via Madonna del Piano 10, 50019 Sesto Fiorentino, Firenze, Italy
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Academic Editor: Giovanna Marrazza
Received: 29 April 2016 / Revised: 7 June 2016 / Accepted: 13 June 2016 / Published: 16 July 2016
(This article belongs to the Special Issue Aptamer Sensors)
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Abstract

In this paper, we review the literature on optical evanescent field sensing in resonant cavities where aptamers are used as biochemical receptors. The combined advantages of highly sensitive whispering gallery mode resonator (WGMR)-based transducers, and of the unique properties of aptamers make this approach extremely interesting in the medical field, where there is a particularly high need for devices able to provide real time diagnosis for cancer, infectious diseases, or strokes. However, despite the superior performances of aptamers compared to antibodies and WGMR to other evanescent sensors, there is not much literature combining both types of receptors and transducers. Up to now, the WGMR that have been used are silica microspheres and silicon oxynitride (SiON) ring resonators. View Full-Text
Keywords: aptamers; whispering gallery mode resonators; microspheres; integrated rings; optical sensors aptamers; whispering gallery mode resonators; microspheres; integrated rings; optical sensors
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nunzi Conti, G.; Berneschi, S.; Soria, S. Aptasensors Based on Whispering Gallery Mode Resonators. Biosensors 2016, 6, 28.

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