Biosensors 2013, 3(3), 259-282; doi:10.3390/bios3030259
Review

The DosS-DosT/DosR Mycobacterial Sensor System

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Received: 21 May 2013; in revised form: 15 June 2013 / Accepted: 26 June 2013 / Published: 4 July 2013
(This article belongs to the Special Issue Physiological Sensors of Gases, Light, Redox State and Hypoxia)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: DosS/DosR is a two-component regulatory system in which DosS, a heme-containing sensor also known as DevS, under certain conditions undergoes autophosphorylation and then transfers the phosphate to DosR, a DNA-binding protein that controls the entry of Mycobacterium tuberculosis and other mycobacteria into a latent, dormant state. DosT, a second sensor closely related to DosS, is present in M. tuberculosis and participates in the control of the dormancy response mediated by DosR. The binding of phosphorylated DosR to DNA initiates the expression of approximately fifty dormancy-linked genes. DosT is accepted to be a gas sensor that is activated in the ferrous state by the absence of an oxygen ligand or by the binding of NO or CO. DosS functions in a similar fashion as a gas sensor, but contradictory evidence has led to the suggestion that it also functions as a redox state sensor. This review focuses on the structure, biophysical properties, and function of the DosS/DosT heme sensors.
Keywords: DevS; DosS; DosT; DosR; Mycobacterium tuberculosis; heme-based sensors; two-component system; nitric oxide; carbon monoxide; hypoxia; dormancy
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MDPI and ACS Style

Sivaramakrishnan, S.; Ortiz de Montellano, P.R. The DosS-DosT/DosR Mycobacterial Sensor System. Biosensors 2013, 3, 259-282.

AMA Style

Sivaramakrishnan S, Ortiz de Montellano PR. The DosS-DosT/DosR Mycobacterial Sensor System. Biosensors. 2013; 3(3):259-282.

Chicago/Turabian Style

Sivaramakrishnan, Santhosh; Ortiz de Montellano, Paul R. 2013. "The DosS-DosT/DosR Mycobacterial Sensor System." Biosensors 3, no. 3: 259-282.

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