Non-Interventional and High-Precision Temperature Measurement Biochips for Long-Term Monitoring the Temperature Fluctuations of Individual Cells
Abstract
:1. Introduction
2. Materials and Methods
2.1. Chip Fabrication
2.2. Molecular Modification of the Surfaces of the Chips
2.3. Cell Culture and Temperature Monitoring
3. Results and Discussions
3.1. Design and Properties of the New Biochip
3.1.1. The Temperature-Measurement Chip and Control System
3.1.2. Improving Cell Compatibility by Molecular Modification of the Chip Surface
3.1.3. High Thermal Sensitivity
3.1.4. Low Thermal Noise
3.2. Preliminary Applications in Temperature-Measurements of Individual Cells
3.2.1. Temperature Fluctuations from the Basic Metabolism of Hela Cells
3.2.2. Temperature Drop of Hela Cells Subjected to a Lethal Fluid
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Han, D.; Xu, J.; Wang, H.; Wang, Z.; Yang, N.; Yang, F.; Shen, Q.; Xu, S. Non-Interventional and High-Precision Temperature Measurement Biochips for Long-Term Monitoring the Temperature Fluctuations of Individual Cells. Biosensors 2021, 11, 454. https://doi.org/10.3390/bios11110454
Han D, Xu J, Wang H, Wang Z, Yang N, Yang F, Shen Q, Xu S. Non-Interventional and High-Precision Temperature Measurement Biochips for Long-Term Monitoring the Temperature Fluctuations of Individual Cells. Biosensors. 2021; 11(11):454. https://doi.org/10.3390/bios11110454
Chicago/Turabian StyleHan, Danhong, Jingjing Xu, Han Wang, Zhenhai Wang, Nana Yang, Fan Yang, Qundong Shen, and Shengyong Xu. 2021. "Non-Interventional and High-Precision Temperature Measurement Biochips for Long-Term Monitoring the Temperature Fluctuations of Individual Cells" Biosensors 11, no. 11: 454. https://doi.org/10.3390/bios11110454