Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation
Abstract
:1. Introduction
2. Materials and Methods
2.1. Selection and Description of Participants
2.2. Dietary Assessment and Dietary Antioxidant Capacity Estimation
2.3. Blood Collection
2.4. Determination of Antioxidant and Oxidant Markers
2.5. Statistics
3. Results
3.1. High Values of Personal Dose Equivalent and Dietary Antioxidant Capacity among Workers from Nuclear Medicine
3.2. Putative Correlation between Impaired Redox Status and Personal Dose Equivalent
3.3. Prominent Imbalance of Redox Status in Workers from Nuclear Medicine
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristics | Control | Group 1 | Group 2 | Group 3 |
---|---|---|---|---|
N of subjects | 28 | 14 9 nurses, 4 physicians, 1 radiographer | 18 6 nurses, 6 physicians,3 physicists, 3 radiographers | 10 5 nurses 1 physician 1 pharmacist 3 radiographers |
Males | 10 | 3 | 8 | 1 |
Females | 18 | 11 | 10 | 9 |
Age (yr) Mean (SEM) | 43 (2) | 48 (1) | 50 (3) | 48 (1) |
Smokers (n smokers/group) | 3/28 | 4/14 | 4/18 | 5/10 |
High Cholesterol (n subjects with >220 mg/dL/group) | 6/28 | 1/14 | 0/18 | 1/10 |
Hypertension (n of subject with ≥140/90 mm Hg/group) | 1/28 | 2/14 | 0/18 | 0/10 |
Vitamins/minerals supplements (n of subject/group) | 1/28 | 1/14 | 0/18 | 0/10 |
ORAC (μmol TE/100 g) Mean (SEM) | 12599 (1449) | 17796 (2615) | 17272 (3039) | 23368 (3716) * |
19074 (1822) (Groups 1–3) | ||||
Hp(10)12 (mSv) Mean (SEM) [Range] | ---- | 0.22 (0.15) [0.0–1.9] | 0.05 (0.03) [0.0–0.6] | 0.45 (0.17) a,b [0.0–1.4] |
0.2 (0.07) [0.0–1.9] (Groups 1–3) | ||||
Hp(0.07)12 (mSv) Mean (SEM) [Range] | ---- | 11.05 (5.66) [1.8–38.7] | 0.12 (0.08) c [0.0–0.5] | 3.14 (1.46) [0.0–11.1] |
4.7 (2.0) [0.0–38.7] (Groups 1–3) | ||||
Cumulative Hp(10) (mSv) Mean (SEM) [Range] | ---- | 5.16 (1.43) [0.0–13.7] | 5.56 (2.67) [0.0–49.8] | 9.8 (6.4) [0.0–65.3] |
6.44 (1.95) [0.1–65.3] (Groups 1–3) |
Variables | Estimate | S. Error | p | Estimate | S. Error | p | Estimate | S. Error | p | Estimate | S. Error | p | Estimate | S. Error | p |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TAC | EC-SOD | GSG/GSSG | TBARS | NOX | |||||||||||
Age | 0.043 | 0.028 | 0.126 | 0.026 | 0.029 | 0.371 | −0.032 | 0.041 | 0.426 | −0.009 | 0.029 | 0.763 | −0.004 | 0.029 | 0.888 |
Gender | 0.749 | 0.626 | 0.232 | −0.202 | 0.672 | 0.764 | −2.745 | 1.293 | 0.034 | −0.302 | 0.707 | 0.669 | −1.385 | 0.658 | 0.035 |
Tobacco | −3.455 | 0.929 | <0.001 | 0.51 | 0.837 | 0.542 | −0.637 | 1.673 | 0.703 | 0.874 | 0.898 | 0.33 | 0.905 | 0.781 | 0.247 |
High Cholesterol | 1.455 | 0.979 | 0.137 | −0.043 | 0.956 | 0.964 | 2.138 | 1.27 | 0.092 | −0.978 | 0.927 | 0.291 | 1.136 | 0.932 | 0.222 |
ORAC | −0.102 | 0.037 | 0.006 | 0.022 | 0.035 | 0.525 | 0.016 | 0.079 | 0.844 | 0.011 | 0.038 | 0.772 | 0.028 | 0.036 | 0.443 |
C vs. Group 1 | −2.364 | 1.058 | 0.025 | −1.276 | 0.919 | 0.165 | 4.983 | 2.186 | 0.023 | −2.34 | 0.959 | 0.015 | 1.276 | 0.927 | 0.169 |
C vs. Group 2 | −2.009 | 0.841 | 0.017 | 0.87 | 0.818 | 0.288 | 4.031 | 1.868 | 0.031 | 0.081 | 0.743 | 0.913 | 2.701 | 0.893 | 0.002 |
C vs. Group 3 | −3.176 | 1.032 | 0.002 | −1.696 | 1.031 | 0.1 | 2.769 | 1.604 | 0.084 | 4.428 | 1.682 | 0.008 | 1.845 | 0.959 | 0.054 |
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Sebastià, N.; Olivares-González, L.; Montoro, A.; Barquinero, J.-F.; Canyada-Martinez, A.J.; Hervás, D.; Gras, P.; Villaescusa, J.I.; Martí-Bonmatí, L.; Muresan, B.T.; et al. Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation. Antioxidants 2020, 9, 778. https://doi.org/10.3390/antiox9090778
Sebastià N, Olivares-González L, Montoro A, Barquinero J-F, Canyada-Martinez AJ, Hervás D, Gras P, Villaescusa JI, Martí-Bonmatí L, Muresan BT, et al. Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation. Antioxidants. 2020; 9(9):778. https://doi.org/10.3390/antiox9090778
Chicago/Turabian StyleSebastià, Natividad, Lorena Olivares-González, Alegría Montoro, Joan-Francesc Barquinero, Antonio José Canyada-Martinez, David Hervás, Pilar Gras, Juan Ignacio Villaescusa, Luis Martí-Bonmatí, Bianca Tabita Muresan, and et al. 2020. "Redox Status, Dose and Antioxidant Intake in Healthcare Workers Occupationally Exposed to Ionizing Radiation" Antioxidants 9, no. 9: 778. https://doi.org/10.3390/antiox9090778