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Antioxidants 2014, 3(3), 569-591; doi:10.3390/antiox3030569

Evaluation of Antioxidant and Hepatoprotective Activities of Moringa oleifera Lam. Leaves in Carbon Tetrachloride-Intoxicated Rats

1
Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur 302 055, India
2
Department of Zoology, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi 110 003, India
*
Author to whom correspondence should be addressed.
Received: 12 June 2014 / Revised: 4 August 2014 / Accepted: 8 August 2014 / Published: 2 September 2014
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Abstract

The antioxidant and hepatoprotective activities of the extract of Moringa oleifera leaves were investigated against CCl4-induced hepatotoxicity in rats. Hepatotoxic rats were treated with ethanol extract of Moringa oleifera for a period of 60 days at the following three dose levels; 100, 200 and 400 mg/kg body weight/day, orally. The activities were studied by assaying the serum marker enzymes like SGOT, SGPT, GGT, LDH, ALP, ACP, as well as total bilirubin, total protein and albumin in serum concomitantly with the activities of LPO, SOD, CAT, GSH, GR and GPx in liver. The activities of all parameters registered a significant (p ≤ 0.001) alteration in CCl4 treated rats, which were significantly recovered towards an almost normal level in rats co-administered with M. oleifera extract in a dose-dependent manner. All the biochemical investigations were confirmed by the histopathological observations and compared with the standard drug. silymarin. Results suggest that the antioxidant and hepatoprotective activities of M. oleifera leaves are possibly related to the free radical scavenging activity which might be due to the presence of total phenolics and flavonoids in the extract and/or the purified compounds β-sitosterol, quercetin and kaempferol, which were isolated from the ethanol extract of M. oleifera leaves. View Full-Text
Keywords: antioxidants; free radicals; hepatoprotection; Moringa oleifera antioxidants; free radicals; hepatoprotection; Moringa oleifera
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Singh, D.; Arya, P.V.; Aggarwal, V.P.; Gupta, R.S. Evaluation of Antioxidant and Hepatoprotective Activities of Moringa oleifera Lam. Leaves in Carbon Tetrachloride-Intoxicated Rats. Antioxidants 2014, 3, 569-591.

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