Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses
AbstractMicroarray technologies inspired the development of carbohydrate arrays. Initially, carbohydrate array technology was hindered by the complex structures of glycans and their structural variability. The first designs of glycoarrays focused on the HTP (high throughput) study of protein–glycan binding events, and subsequently more in-depth kinetic analysis of carbohydrate–protein interactions. However, the applications have rapidly expanded and now achieve successful discrimination of selective interactions between carbohydrates and, not only proteins, but also viruses, bacteria and eukaryotic cells, and most recently even live cell responses to immobilized glycans. Combining array technology with other HTP technologies such as mass spectrometry is expected to allow even more accurate and sensitive analysis. This review provides a broad overview of established glycoarray technologies (with a special focus on glycosaminoglycan applications) and their emerging applications to the study of complex interactions between glycans and whole living cells. View Full-Text
Scifeed alert for new publicationsNever miss any articles matching your research from any publisher
- Get alerts for new papers matching your research
- Find out the new papers from selected authors
- Updated daily for 49'000+ journals and 6000+ publishers
- Define your Scifeed now
Puvirajesinghe, T.M.; Turnbull, J.E. Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses. Microarrays 2016, 5, 3.
Puvirajesinghe TM, Turnbull JE. Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses. Microarrays. 2016; 5(1):3.Chicago/Turabian Style
Puvirajesinghe, Tania M.; Turnbull, Jeremy. E. 2016. "Glycoarray Technologies: Deciphering Interactions from Proteins to Live Cell Responses." Microarrays 5, no. 1: 3.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.