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Copy Number Variation in Chickens: A Review and Future Prospects
Department of Biological Sciences, Tennessee State University, 3500 John A. Merritt Blvd., Nashville, TN 37209, USA
* Author to whom correspondence should be addressed.
Received: 15 December 2013; in revised form: 22 January 2014 / Accepted: 23 January 2014 / Published: 5 February 2014
Abstract: DNA sequence variations include nucleotide substitution, deletion, insertion, translocation and inversion. Deletion or insertion of a large DNA segment in the genome, referred to as copy number variation (CNV), has caught the attention of many researchers recently. It is believed that CNVs contribute significantly to genome variability, and thus contribute to phenotypic variability. In chickens, genome-wide surveys with array comparative genome hybridization (aCGH), SNP chip detection or whole genome sequencing have revealed a large number of CNVs. A large portion of chicken CNVs involves protein coding or regulatory sequences. A few CNVs have been demonstrated to be the determinant factors for single gene traits, such as late-feathering, pea-comb and dermal hyperpigmentation. The phenotypic effects of the majority of chicken CNVs are to be delineated.
Keywords: copy number variation; phenotypic variability; chicken
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Wang, X.; Byers, S. Copy Number Variation in Chickens: A Review and Future Prospects. Microarrays 2014, 3, 24-38.
Wang X, Byers S. Copy Number Variation in Chickens: A Review and Future Prospects. Microarrays. 2014; 3(1):24-38.
Wang, Xiaofei; Byers, Shannon. 2014. "Copy Number Variation in Chickens: A Review and Future Prospects." Microarrays 3, no. 1: 24-38.