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Microarrays 2014, 3(1), 24-38; doi:10.3390/microarrays3010024
Review

Copy Number Variation in Chickens: A Review and Future Prospects

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Received: 15 December 2013; in revised form: 22 January 2014 / Accepted: 23 January 2014 / Published: 5 February 2014
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Abstract: DNA sequence variations include nucleotide substitution, deletion, insertion, translocation and inversion. Deletion or insertion of a large DNA segment in the genome, referred to as copy number variation (CNV), has caught the attention of many researchers recently. It is believed that CNVs contribute significantly to genome variability, and thus contribute to phenotypic variability. In chickens, genome-wide surveys with array comparative genome hybridization (aCGH), SNP chip detection or whole genome sequencing have revealed a large number of CNVs. A large portion of chicken CNVs involves protein coding or regulatory sequences. A few CNVs have been demonstrated to be the determinant factors for single gene traits, such as late-feathering, pea-comb and dermal hyperpigmentation. The phenotypic effects of the majority of chicken CNVs are to be delineated.
Keywords: copy number variation; phenotypic variability; chicken copy number variation; phenotypic variability; chicken
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, X.; Byers, S. Copy Number Variation in Chickens: A Review and Future Prospects. Microarrays 2014, 3, 24-38.

AMA Style

Wang X, Byers S. Copy Number Variation in Chickens: A Review and Future Prospects. Microarrays. 2014; 3(1):24-38.

Chicago/Turabian Style

Wang, Xiaofei; Byers, Shannon. 2014. "Copy Number Variation in Chickens: A Review and Future Prospects." Microarrays 3, no. 1: 24-38.

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