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Microorganisms 2018, 6(2), 39; https://doi.org/10.3390/microorganisms6020039

The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding?

1
LISBP, Université de Toulouse, CNRS, INRA, INSA, 31400 Toulouse, France
2
Department of Biotechnology and Food Science, NTNU the Norwegian University of Science and Technology, NO-7491 Trondheim, Norway
3
LAAS-CNRS, Université de Toulouse, CNRS, 31400 Toulouse, France
*
Author to whom correspondence should be addressed.
Received: 22 March 2018 / Revised: 24 April 2018 / Accepted: 26 April 2018 / Published: 4 May 2018
(This article belongs to the Special Issue Gut Bacteria-Mucus Interaction)
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Abstract

Bacterial adhesion is currently the subject of increased interest from the research community, leading to fast progress in our understanding of this complex phenomenon. Resent research within this field has documented the important roles played by glycans for bacterial surface adhesion, either through interaction with lectins or with other glycans. In parallel with this increased interest for and understanding of bacterial adhesion, there has been a growth in the sophistication and use of sensitive force probes for single-molecule and single cell studies. In this review, we highlight how the sensitive force probes atomic force microscopy (AFM) and optical tweezers (OT) have contributed to clarifying the mechanisms underlying bacterial adhesion to glycosylated surfaces in general and mucosal surfaces in particular. We also describe research areas where these techniques have not yet been applied, but where their capabilities appear appropriate to advance our understanding. View Full-Text
Keywords: carbohydrate recognition; mucus; adhesins; lectins; mucus adhesion; glycan interactions; AFM; optical tweezers carbohydrate recognition; mucus; adhesins; lectins; mucus adhesion; glycan interactions; AFM; optical tweezers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Formosa-Dague, C.; Castelain, M.; Martin-Yken, H.; Dunker, K.; Dague, E.; Sletmoen, M. The Role of Glycans in Bacterial Adhesion to Mucosal Surfaces: How Can Single-Molecule Techniques Advance Our Understanding? Microorganisms 2018, 6, 39.

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