Next Article in Journal
The Potential of Acousto-Ultrasonic Techniques for Inspection of Baked Carbon Anodes
Previous Article in Journal
In Vitro Analysis of the Tribological Behaviour of Different Material Combinations for Telescopic Crowns
Previous Article in Special Issue
Effect of BaO Addition on Densification and Mechanical Properties of Al2O3-MgO-CaO Refractories
Article Menu

Export Article

Open AccessArticle
Metals 2016, 6(7), 150; doi:10.3390/met6070150

Effects of Surface Structure and Chemical Composition of Binary Ti Alloys on Cell Differentiation

Department of Dental Materials and Medical Research Center for Biomineralization Disorders, School of Dentistry, Chonnam National University, Gwangju 61186, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Rita Khanna
Received: 1 March 2016 / Revised: 21 May 2016 / Accepted: 30 June 2016 / Published: 4 July 2016
(This article belongs to the Special Issue Refractory Metals and Alloys)
View Full-Text   |   Download PDF [4725 KB, uploaded 4 July 2016]   |  

Abstract

Binary Ti alloys containing Fe, Mo, V and Zr were micro-arc oxidized and hydrothermally treated to obtain micro- and nano-porous layers. This study aimed to investigate cell differentiation on micro and micro/nanoporous oxide layers of Ti alloys. The properties of the porous layer formed on Ti alloys were characterized by X-ray diffraction pattern, microstructural and elemental analyses and inductively coupled plasma mass spectrometry (ICP-MS) method. The MTT assay, total protein production and alkaline phosphatase (ALPase) activity were evaluated using human osteoblast-like cells (MG-63). Microporous structures of micro-arc oxidized Ti alloys were changed to micro/nanoporous surfaces after hydrothermal treatment. Micro/nanoporous surfaces consisted of acicular TiO2 nanoparticles and micron-sized hydroxyapatite particles. From ICP and MTT tests, the Mo and V ions released from porous oxide layers were positive for cell viability, while the released Fe ions were negative for cell viability. Although the micro/nanoporous surfaces led to a lower total protein content than the polished and microporous Ti surfaces after cell incubation for 7 days, they caused higher ALPase activities after 7 days and 14 days of incubation except for V-containing microporous surfaces. The micro/nanoporous surfaces of Ti alloys were more efficient in inducing MG-63 cell differentiation. View Full-Text
Keywords: Ti alloys; micro-arc oxidation; hydrothermal treatment; cell differentiation Ti alloys; micro-arc oxidation; hydrothermal treatment; cell differentiation
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Han, O.-S.; Hwang, M.-J.; Song, Y.-H.; Song, H.-J.; Park, Y.-J. Effects of Surface Structure and Chemical Composition of Binary Ti Alloys on Cell Differentiation. Metals 2016, 6, 150.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Metals EISSN 2075-4701 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top