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Diagnostics 2017, 7(3), 42; doi:10.3390/diagnostics7030042

Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside

Department of Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, Münster 48149, Germany
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Received: 6 May 2017 / Revised: 21 June 2017 / Accepted: 6 July 2017 / Published: 13 July 2017
(This article belongs to the Special Issue Alzheimer's Disease Imaging Biomarkers)
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Abstract

Alzheimer’s disease is the most common cause of dementia. Over the last three decades, research has advanced dramatically and provided a detailed understanding of the molecular events underlying the pathogenesis of Alzheimer’s disease. In parallel, assays for the detection of biomarkers that reflect the typical Alzheimer’s disease-associated pathology have been developed and validated in myriads of clinical studies. Such biomarkers complement clinical diagnosis and improve diagnostic accuracy. The use of biomarkers will become even more important with the advent of disease-modifying therapies. Such therapies will likely be most beneficial when administered early in the disease course. Here, we summarise the development of the core Alzheimer’s disease cerebrospinal fluid biomarkers: amyloid-β and tau. We provide an overview of their role in cellular physiology and Alzheimer’s disease pathology, and embed their development as cerebrospinal fluid biomarkers into the historical context of Alzheimer’s disease research. Finally, we summarise recommendations for their use in clinical practice, and outline perspectives for novel cerebrospinal fluid candidate biomarkers. View Full-Text
Keywords: Alzheimer’s disease; dementia; fluid biomarkers; cerebrospinal fluid; amyloid-β; tau Alzheimer’s disease; dementia; fluid biomarkers; cerebrospinal fluid; amyloid-β; tau
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Pawlowski, M.; Meuth, S.G.; Duning, T. Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease—From Brain Starch to Bench and Bedside. Diagnostics 2017, 7, 42.

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