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Diagnostics 2017, 7(2), 35; doi:10.3390/diagnostics7020035

Dynamic Contrast-Enhanced Ultrasound of Colorectal Liver Metastases as an Imaging Modality for Early Response Prediction to Chemotherapy

1
Department of Oncology, Copenhagen University, Rigshospitalet, Copenhagen 2100, Denmark
2
Department of Radiology, Copenhagen University, Rigshospitalet, Copenhagen 2100, Denmark
3
Department of Pathology, Copenhagen University, Rigshospitalet, Copenhagen 2100, Denmark
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 4 March 2017 / Revised: 21 May 2017 / Accepted: 6 June 2017 / Published: 12 June 2017
(This article belongs to the Special Issue Imaging of Early Response in Cancer Management)
View Full-Text   |   Download PDF [1266 KB, uploaded 12 June 2017]   |  

Abstract

Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or without bevacizumab. DCE-US was performed before therapy (baseline) and again 10 days after initiation of treatment. Change in contrast-enhancement in one liver metastasis (indicator lesion) was measured. Treatment response was evaluated with a computed tomography (CT) scan after three cycles of treatment and the initially observed DCE-US change of the indicator lesion was related to the observed CT response. Eighteen patients were included. Six did not complete three series of chemotherapy and the evaluation CT scan, leaving twelve patients for analysis. Early changes in perfusion parameters using DCE-US did not correlate well with subsequent CT changes. A subgroup analysis of eight patients receiving bevacizumab, however, demonstrated a statistically significant correlation (p = 0.045) between early changes in perfusion measures of peak enhancement at DCE-US and tumor shrinkage at CT scan. The study indicates that early changes in DCE-US perfusion measures may predict subsequent treatment response of colorectal liver metastases in patients receiving bevacizumab. View Full-Text
Keywords: dynamic contrast-enhanced ultrasound (DCE-US); colorectal cancer; early response evaluation; liver metastases dynamic contrast-enhanced ultrasound (DCE-US); colorectal cancer; early response evaluation; liver metastases
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Mogensen, M.B.; Hansen, M.L.; Henriksen, B.M.; Axelsen, T.; Vainer, B.; Osterlind, K.; Nielsen, M.B. Dynamic Contrast-Enhanced Ultrasound of Colorectal Liver Metastases as an Imaging Modality for Early Response Prediction to Chemotherapy. Diagnostics 2017, 7, 35.

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