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Diagnostics 2017, 7(2), 31; doi:10.3390/diagnostics7020031

Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by 82Rb PET/CT in HIV-Infected Patients

Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre 2650, Denmark
Department of Clinical Physiology, Nuclear Medicine & PET, and Cluster for Molecular Imaging, Copenhagen University Hospital, Rigshospitalet and University of Copenhagen, Copenhagen 2100, Denmark
Author to whom correspondence should be addressed.
Academic Editor: Kalevi Kairemo
Received: 20 February 2017 / Revised: 30 April 2017 / Accepted: 26 May 2017 / Published: 31 May 2017
(This article belongs to the Section Medical Imaging)
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After the introduction of antiretroviral therapy (ART) the life expectancy of patients infected with human immunodeficiency virus (HIV) is now approaching that of the general population and the importance of non-AIDS co-morbidities is increasing. Specifically, the risk of coronary artery disease (CAD) seems to be higher in HIV-infected patients and an accurate risk prediction of CAD is of high importance for optimal long term treatment. In this study, we assessed the correlation of the endoPAT, which is an office-based CVD screening tool with the myocardial perfusion reserve by 82-rubidium PET/CT. We measured the reactive hyperemia index, which is a measure of the endothelial responsiveness, by the use of an endoPAT device (Itamar Medical, Caesarea, Israel) in 48 ART treated HIV-infected patients with high CD 4 cell counts and viral suppression (HIV-RNA < 20 copies/mL), who had previously undergone measurement of the myocardial perfusion reserve by 82-rubidium PET/CT for study purposes. We found an inverse correlation between the reactive hyperemia index and the myocardial perfusion reserve which most likely indicates different vascular physiology. This study did not find evidence to suggest the immediate implementation of the reactive hyperemia index as a screening tool for early coronary artery disease in well-treated HIV-infected patients pending further validation in larger prospective studies. View Full-Text
Keywords: reactive hyperemia index; HIV; cardiovascular risk; myocardial perfusion reserve reactive hyperemia index; HIV; cardiovascular risk; myocardial perfusion reserve

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ørbæk, M.; Hasbak, P.; Sejersten Ripa, R.; Kjær, A.; Lebech, A.-M.; Knudsen, A. Comparison of the Peripheral Reactive Hyperemia Index with Myocardial Perfusion Reserve by 82Rb PET/CT in HIV-Infected Patients. Diagnostics 2017, 7, 31.

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