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Diagnostics 2016, 6(3), 28; doi:10.3390/diagnostics6030028

Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT

Department of Diagnostic Radiology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark
Department of Technology, Faculty of Health and Technology, Metropolitan University College, 2200 Copenhagen, Denmark
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 25 April 2016 / Revised: 12 July 2016 / Accepted: 15 July 2016 / Published: 21 July 2016
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The aim of this study was to provide an overview of the literature available on dynamic contrast-enhanced computed tomography (DCE-CT) as a tool to evaluate treatment response in patients with lung cancer. This systematic review was compiled according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only original research articles concerning treatment response in patients with lung cancer assessed with DCE-CT were included. To assess the validity of each study we implemented Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). The initial search yielded 651 publications, and 16 articles were included in this study. The articles were divided into groups of treatment. In studies where patients were treated with systemic chemotherapy with or without anti-angiogenic drugs, four out of the seven studies found a significant decrease in permeability after treatment. Four out of five studies that measured blood flow post anti-angiogenic treatments found that blood flow was significantly decreased. DCE-CT may be a useful tool in assessing treatment response in patients with lung cancer. It seems that particularly permeability and blood flow are important perfusion values for predicting treatment outcome. However, the heterogeneity in scan protocols, scan parameters, and time between scans makes it difficult to compare the included studies. View Full-Text
Keywords: DCE-CT; Dynamic Contrast-Enhanced CT; lung cancer; treatment response DCE-CT; Dynamic Contrast-Enhanced CT; lung cancer; treatment response

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Strauch, L.S.; Eriksen, R.Ø.; Sandgaard, M.; Kristensen, T.S.; Nielsen, M.B.; Lauridsen, C.A. Assessing Tumor Response to Treatment in Patients with Lung Cancer Using Dynamic Contrast-Enhanced CT. Diagnostics 2016, 6, 28.

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