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Diagnostics 2016, 6(2), 23; doi:10.3390/diagnostics6020023

Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases

Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, Uchinada-machi, Kahoku, Ishikawa 920-0293, Japan
Academic Editor: Ludmilla A. Morozova-Roche
Received: 25 March 2016 / Revised: 30 May 2016 / Accepted: 1 June 2016 / Published: 7 June 2016
(This article belongs to the Special Issue Biomarkers in Blood 2016)
View Full-Text   |   Download PDF [1903 KB, uploaded 7 June 2016]   |  

Abstract

Advanced glycation end-products (AGEs) generated with aging or in the presence of diabetes mellitus, particularly AGEs derived from the glucose/fructose metabolism intermediate glyceraldehyde (Glycer-AGEs; termed toxic AGEs (TAGE)), were recently shown to be closely involved in the onset/progression of diabetic vascular complications via the receptor for AGEs (RAGE). TAGE also contribute to various diseases, such as cardiovascular disease; nonalcoholic steatohepatitis; cancer; Alzheimer’s disease, and; infertility. This suggests the necessity of minimizing the influence of the TAGE-RAGE axis in order to prevent the onset/progression of lifestyle-related diseases (LSRD) and establish therapeutic strategies. Changes in serum TAGE levels are closely associated with LSRD related to overeating, a lack of exercise, or excessive ingestion of sugars/dietary AGEs. We also showed that serum TAGE levels, but not those of hemoglobin A1c, glucose-derived AGEs, or Nε-(carboxymethyl)lysine, have potential as a biomarker for predicting the progression of atherosclerosis and future cardiovascular events. We herein introduce the usefulness of serum TAGE levels as a biomarker for the prevention/early diagnosis of LSRD and the evaluation of the efficacy of treatments; we discuss whether dietary AGE/sugar intake restrictions reduce the generation/accumulation of TAGE, thereby preventing the onset/progression of LSRD. View Full-Text
Keywords: advanced glycation end-products (AGEs); biomarker; toxic AGEs (TAGE); receptor for AGEs (RAGE); cardiovascular disease (CVD); nonalcoholic steatohepatitis (NASH); cancer; Alzheimer’s disease (AD); infertility; lifestyle-related diseases (LSRD) advanced glycation end-products (AGEs); biomarker; toxic AGEs (TAGE); receptor for AGEs (RAGE); cardiovascular disease (CVD); nonalcoholic steatohepatitis (NASH); cancer; Alzheimer’s disease (AD); infertility; lifestyle-related diseases (LSRD)
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Takeuchi, M. Serum Levels of Toxic AGEs (TAGE) May Be a Promising Novel Biomarker for the Onset/Progression of Lifestyle-Related Diseases. Diagnostics 2016, 6, 23.

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