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Diagnostics 2016, 6(1), 8; doi:10.3390/diagnostics6010008

Interobserver and Intraobserver Reproducibility with Volume Dynamic Contrast Enhanced Computed Tomography (DCE-CT) in Gastroesophageal Junction Cancer

1
Department of Radiology, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark
2
Department of Radiology, Koege and Roskilde Hospital, DK-4000 Roskilde, Denmark
3
Metropolitan University College, Radiography Education, Copenhagen, DK-2200 Copenhagen, Denmark
4
Department of Surgery, University Hospital of Copenhagen, Rigshospitalet, DK-2100 Copenhagen, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 10 December 2015 / Revised: 20 January 2016 / Accepted: 26 January 2016 / Published: 1 February 2016
(This article belongs to the Collection Feature Papers)
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Abstract

The purpose of this study was to assess inter- and intra-observer reproducibility of three different analytic methods to evaluate quantitative dynamic contrast-enhanced computed tomography (DCE-CT) measures from gastroesophageal junctional cancer. Twenty-five DCE-CT studies with gastroesophageal junction cancer were selected from a previous longitudinal study. Three radiologists independently reviewed all scans, and one repeated the analysis eight months later for intraobserver analysis. Review of the scans consisted of three analysis methods: (I) Four, fixed small sized regions of interest (2-dimensional (2D) fixed ROIs) placed in the tumor periphery, (II) 2-dimensional regions of interest (2D-ROI) along the tumor border in the tumor center, and (III) 3-dimensional volumes of interest (3D-VOI) containing the entire tumor volume. Arterial flow, blood volume and permeability (ktrans) were recorded for each observation. Inter- and intra-observer variability were assessed by Intraclass Correlation Coefficient (ICC) and Bland-Altman statistics. Interobserver ICC was excellent for arterial flow (0.88), for blood volume (0.89) and for permeability (0.91) with 3D-VOI analysis. The 95% limits of agreement were narrower for 3D analysis compared to 2D analysis. Three-dimensional volume DCE-CT analysis of gastroesophageal junction cancer provides higher inter- and intra-observer reproducibility with narrower limits of agreement between readers compared to 2D analysis. View Full-Text
Keywords: dynamic contrast enhanced computed tomography; imaging biomarkers; gastroesophageal cancer; CT perfusion; reproducibility dynamic contrast enhanced computed tomography; imaging biomarkers; gastroesophageal cancer; CT perfusion; reproducibility
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Lundsgaard Hansen, M.; Fallentin, E.; Axelsen, T.; Lauridsen, C.; Norling, R.; Svendsen, L.B.; Nielsen, M.B. Interobserver and Intraobserver Reproducibility with Volume Dynamic Contrast Enhanced Computed Tomography (DCE-CT) in Gastroesophageal Junction Cancer. Diagnostics 2016, 6, 8.

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