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Diagnostics 2015, 5(4), 399-412; doi:10.3390/diagnostics5040399

Scintigraphic Small Intestinal Transit Time and Defaecography in Patients with J-Pouch

1
Department of Surgery, Odense University Hospital, 29 Sdr. Boulevard, 5000 Odense, Denmark
2
Department of Nuclear Medicine, Odense University Hospital, 29 Sdr. Boulevard, 5000 Odense, Denmark
3
Department of Medical Gastroenterology, Odense University Hospital, 29 Sdr. Boulevard, 5000 Odense, Denmark
4
Centre of Health Economics Research, University of Southern Denmark, Campusvej 55, 5230 Odense, Denmark
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 17 July 2015 / Revised: 10 September 2015 / Accepted: 28 September 2015 / Published: 10 October 2015
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Abstract

Objective methods for examination of pouch function are warranted for a better understanding of the functional result and treatment of dysfunction. The objective of this study was to evaluate the results of scintigraphic intestinal transit time and defaecography compared to the results of pouch function, mucosal condition and a questionnaire on quality of life (QoL). This cross-sectional study included 21 patients. Scintigraphic transit time and defaecography was determined with the use of Tc-99m. Pouch function was assessed by number of bowel movements, pouch volume, and continence. Pouch mucosal condition was evaluated by endoscopy and histology. Median transit time was 189 min (105–365). Median ejection fraction at defaecography (EF) was 49% (3–77) and 62% (17–98) after first and second defecation. Median pouch volume was 223 mL (100–360). A median daily stool frequency of nine (4–25) was reported and three (14%) patients suffered from daytime incontinence. No patients had symptomatic or endoscopic pouchitis; however, the histology showed unspecific inflammation in 19 (90%) patients. There was no correlation between transit time, evacuation fraction (EF) and pouch function in univariate analysis. However, we found a high body mass index (BMI) and a low bowel movement frequency to be associated with a longer transit time by multivariate analysis. Scintigraphic determination of transit time and defaecography are feasible methods in patients with ileal pouch anal anastomosis, but the clinical relevance is yet doubtful. View Full-Text
Keywords: scintigraphic small intestinal transit time; scintigraphic defaecography; ileal pouch-anal anastomosis; IPAA; ulcerative colitis scintigraphic small intestinal transit time; scintigraphic defaecography; ileal pouch-anal anastomosis; IPAA; ulcerative colitis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kjaer, M.D.; Simonsen, J.A.; Hvidsten, S.; Kjeldsen, J.; Gerke, O.; Qvist, N. Scintigraphic Small Intestinal Transit Time and Defaecography in Patients with J-Pouch. Diagnostics 2015, 5, 399-412.

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