Next Article in Journal
Contrast Enhanced MRI in the Diagnosis of HCC
Next Article in Special Issue
Ultrasonography of the Kidney: A Pictorial Review
Previous Article in Journal
Pelvic Actinomycosis Associated with an Intrauterine Contraceptive Device Demonstrated on F-18 FDG PET/CT
Previous Article in Special Issue
Neuroendocrine Carcinomas of the Gastroenteropancreatic System: A Comprehensive Review
Article Menu

Export Article

Open AccessCase Report
Diagnostics 2015, 5(3), 372-382; doi:10.3390/diagnostics5030372

Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring

1
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlaegevej 16, DK-1870 Frederiksberg C, Denmark
2
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen N, Denmark
3
Department of Radiation Oncology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, DK-2200 Copenhagen N, Denmark
4
Department of Micro- and Nanotechnology, Technical University of Denmark, Ørsteds Plads, Building 345E, DK-2800 Kgs. Lyngby, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Graham Jackson
Received: 1 June 2015 / Revised: 27 August 2015 / Accepted: 3 September 2015 / Published: 11 September 2015
(This article belongs to the Collection Feature Papers)
View Full-Text   |   Download PDF [1297 KB, uploaded 11 September 2015]   |  

Abstract

Glycolysis, hypoxia, and proliferation are important factors in the tumor microenvironment contributing to treatment-resistant aggressiveness. Imaging these factors using combined functional positron emission tomography and computed tomography can potentially guide diagnosis and management of cancer patients. A dog with fibrosarcoma was imaged using 18F-FDG, 64Cu-ATSM, and 18F-FLT before, during, and after 10 fractions of 4.5 Gy radiotherapy. Uptake of all tracers decreased during treatment. Fluctuations in 18F-FDG and 18F-FLT PET uptakes and a heterogeneous spatial distribution of the three tracers were seen. Tracer distributions partially overlapped. It appears that each tracer provides distinct information about tumor heterogeneity and treatment response. View Full-Text
Keywords: 18F-FDG; 18F-FLT; 64Cu-ATSM; positron emission tomography; PET/CT; individualized response monitoring; canine fibrosarcoma 18F-FDG; 18F-FLT; 64Cu-ATSM; positron emission tomography; PET/CT; individualized response monitoring; canine fibrosarcoma
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Zornhagen, K.W.; Clausen, M.M.; Hansen, A.E.; Law, I.; McEvoy, F.J.; Engelholm, S.A.; Kjær, A.; Kristensen, A.T. Use of Molecular Imaging Markers of Glycolysis, Hypoxia and Proliferation (18F-FDG, 64Cu-ATSM and 18F-FLT) in a Dog with Fibrosarcoma: The Importance of Individualized Treatment Planning and Monitoring. Diagnostics 2015, 5, 372-382.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Diagnostics EISSN 2075-4418 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top