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Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects
Department of Diagnostic Radiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
Metropolitan University College, Radiography Education, Sigurdsgade 26, Copenhagen 2200, Denmark
Department of Oncology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
Department of Cardiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
Department of Surgery C, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark
* Author to whom correspondence should be addressed.
Received: 18 February 2013; in revised form: 21 March 2013 / Accepted: 25 March 2013 / Published: 3 April 2013
Abstract: Computed Tomography (CT) Perfusion is an evolving method to visualize perfusion in organs and tissue. With the introduction of multidetector CT scanners, it is now possible to cover up to 16 cm in one rotation, and thereby making it possible to scan entire organs such as the liver with a fixed table position. Advances in reconstruction algorithms make it possible to reduce the radiation dose for each examination to acceptable levels. Regarding abdominal imaging, CT perfusion is still considered a research tool, but several studies have proven it as a reliable non-invasive technique for assessment of vascularity. CT perfusion has also been used for tumor characterization, staging of disease, response evaluation of newer drugs targeted towards angiogenesis and as a method for early detection of recurrence after radiation and embolization. There are several software solutions available on the market today based on different perfusion algorithms. However, there is no consensus on which protocol and algorithm to use for specific organs. In this article, the authors give an introduction to CT perfusion in abdominal imaging introducing technical aspects for calculation of perfusion parameters, and considerations on patient preparation. This article also contains clinical cases to illustrate the use of CT perfusion in abdominal imaging.
Keywords: CT Perfusion; cancer imaging; abdominal imaging; motion correction
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MDPI and ACS Style
Hansen, M.L.; Norling, R.; Lauridsen, C.; Fallentin, E.; Bæksgaard, L.; Kofoed, K.F.; Svendsen, L.B.; Nielsen, M.B. Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects. Diagnostics 2013, 3, 261-270.
Hansen ML, Norling R, Lauridsen C, Fallentin E, Bæksgaard L, Kofoed KF, Svendsen LB, Nielsen MB. Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects. Diagnostics. 2013; 3(2):261-270.
Hansen, Martin L.; Norling, Rikke; Lauridsen, Carsten; Fallentin, Eva; Bæksgaard, Lene; Kofoed, Klaus F.; Svendsen, Lars B.; Nielsen, Michael B. 2013. "Computed Tomography (CT) Perfusion in Abdominal Cancer: Technical Aspects." Diagnostics 3, no. 2: 261-270.