Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy
Abstract
:1. Introduction
2. Materials and Methods
Statistical Analyses
3. Results
3.1. Clinical Features of the Examined Patient Groups
3.2. Structural–Functional Changes
3.3. Risk Factors for Elevated IOP in Subjects with GO
4. Discussion
4.1. Clinical Features of the Examined Patient Groups
4.2. Structural and Functional Changes
4.3. Risk Factors for Elevated IOP in Subjects with GO
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Group | N | Min | Max | Centile | p | |||
---|---|---|---|---|---|---|---|---|
25. | Median | 75. | ||||||
Age (yrs) | GO | 48 | 22.00 | 81.00 | 45.50 | 55.50 | 63.50 | <0.001 |
GO IOP | 50 | 28.00 | 77.00 | 52.50 | 61.50 | 68.25 | ||
POAG | 84 | 18.00 | 90.00 | 57.25 | 65.00 | 73.00 | ||
BCVA | GO | 94 | 0.80 | 1.00 | 1.00 | 1.00 | 1.00 | <0.001 |
GO IOP | 97 | 0.80 | 1.00 | 0.90 | 1.00 | 1.00 | ||
POAG | 153 | 0.80 | 1.00 | 0.80 | 1.00 | 1.00 | ||
IOP (mmHg) | GO | 94 | 10.00 | 20.00 | 14.00 | 16.00 | 17.00 | <0.001 |
GO IOP | 97 | 21.00 | 28.00 | 22.00 | 24.00 | 26.00 | ||
POAG | 153 | 10.00 | 26.00 | 18.00 | 20.00 | 22.50 | ||
CCT (μm) | GO | 94 | 465.00 | 617.00 | 531.75 | 555.50 | 575.25 | <0.001 |
GO IOP | 97 | 433.00 | 658.00 | 521.00 | 541.00 | 563.50 | ||
POAG | 153 | 450.00 | 669.00 | 506.00 | 535.00 | 558.50 | ||
Exophthalmometry (mm) | GO | 94 | 10.00 | 27.00 | 16.00 | 18.00 | 21.00 | <0.001 |
GO IOP | 97 | 11.00 | 29.00 | 17.00 | 20.00 | 23.00 | ||
POAG | 153 | 13.00 | 19.00 | 15.00 | 16.00 | 17.00 |
Group | N | Min | Max | Centile | p | |||
---|---|---|---|---|---|---|---|---|
25. | Median | 75. | ||||||
CAS | GO | 94 | 0.00 | 3.00 | 0.00 | 0.00 | 1.00 | <0.001 |
GO IOP | 97 | 0.00 | 5.00 | 1.00 | 1.00 | 3.00 | ||
NOSPECS classification | GO | 94 | 0.00 | 3.00 | 0.00 | 1.00 | 2.00 | <0.001 |
GO IOP | 97 | 0.00 | 3.00 | 1.00 | 2.00 | 3.00 |
Group | N | Min | Max | Centile | p | |||
---|---|---|---|---|---|---|---|---|
25. | Median | 75. | ||||||
RNFL (μm) | GO | 94 | 61.00 | 113.00 | 83.00 | 89.50 | 96.25 | <0.001 |
GO IOP | 97 | 66.00 | 110.00 | 85.00 | 89.00 | 94.00 | ||
POAG | 153 | 49.00 | 111.00 | 63.00 | 80.00 | 89.00 | ||
Rim area (mm2) | GO | 94 | 1.00 | 2.13 | 1.30 | 1.51 | 1.66 | <0.001 |
GO IOP | 97 | 0.87 | 2.09 | 1.20 | 1.35 | 1.53 | ||
POAG | 153 | 0.21 | 2.80 | 0.87 | 1.09 | 1.32 | ||
Disc area (mm2) | GO | 94 | 1.12 | 2.85 | 1.66 | 1.85 | 2.08 | 0.327 |
GO IOP | 97 | 1.27 | 2.83 | 1.68 | 1.96 | 2.17 | ||
POAG | 153 | 0.78 | 3.25 | 1.59 | 1.90 | 2.24 | ||
Average c/d ratio | GO | 94 | 0.07 | 0.70 | 0.30 | 0.40 | 0.55 | <0.001 |
GO IOP | 97 | 0.12 | 0.71 | 0.40 | 0.50 | 0.62 | ||
POAG | 153 | 0.05 | 0.93 | 0.56 | 0.65 | 0.74 | ||
Vertical c/d ratio | GO | 94 | 0.06 | 0.66 | 0.30 | 0.40 | 0.51 | <0.001 |
GO IOP | 97 | 0.09 | 0.74 | 0.41 | 0.50 | 0.60 | ||
POAG | 153 | 0.05 | 0.91 | 0.55 | 0.62 | 0.75 | ||
Cup volume (mm3) | GO | 94 | 0.00 | 0.66 | 0.02 | 0.06 | 0.15 | <0.001 |
GO IOP | 97 | 0.00 | 0.51 | 0.03 | 0.09 | 0.23 | ||
POAG | 153 | 0.00 | 1.43 | 0.14 | 0.25 | 0.40 |
r2 = 50.3%; p = 0.001 | OR | 95% CI | p | |
---|---|---|---|---|
Low | High | |||
Age (yrs) | 1.08 | 1.01 | 1.15 | 0.026 * |
Female sex | 2.96 | 0.51 | 17.19 | 0.226 |
Smoking | 2.40 | 0.47 | 12.30 | 0.294 |
Arterial Hypertension | 3.51 | 0.55 | 22.29 | 0.183 |
DM | 1.36 | 0.11 | 16.57 | 0.812 |
Stress at the time of diagnosis of thyroid disease | 0.90 | 0.18 | 4.37 | 0.892 |
Thyroid function on diagnosis of GO: hipo | 0.305 | |||
Thyroid function on diagnosis of GO: eu | 6.96 | 0.57 | 84.56 | 0.128 |
Thyroid function on diagnosis of GO: hiper | 2.97 | 0.36 | 24.14 | 0.309 |
TSH < 0.35 mIU/L | 0.498 | |||
TSH 0.35–4.94 mIU/L | 2.62 | 0.26 | 25.96 | 0.411 |
TSH > 4.94 mIU/L | 0.77 | 0.04 | 14.84 | 0.860 |
fT3 < 3.8 pmol/L | 0.141 | |||
FT3 3.8–6.0 pmol/L | 0.57 | 0.12 | 2.69 | 0.481 |
FT3 > 6 pmol/L | 22.95 | 0.89 | 591.99 | 0.059 |
fT4 < 9.0 pmol/L | 0.114 | |||
FT4 9.0–19.0 pmol/L | 0.00 | 0.00 | 0.999 | |
FT4 > 19.0 pmol/L | 0.00 | 0.00 | 0.999 | |
Anti-TSHR elevated values | 0.41 | 0.11 | 1.52 | 0.184 |
Anti-TPO elevated values | 1.46 | 0.26 | 8.13 | 0.663 |
Anti-TG elevated values | 21.00 | 1.59 | 278.06 | 0.021 * |
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Bagatin, F.; Prpić, A.; Škunca Herman, J.; Zrinšćak, O.; Iveković, R.; Vatavuk, Z. Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy. Diagnostics 2024, 14, 649. https://doi.org/10.3390/diagnostics14060649
Bagatin F, Prpić A, Škunca Herman J, Zrinšćak O, Iveković R, Vatavuk Z. Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy. Diagnostics. 2024; 14(6):649. https://doi.org/10.3390/diagnostics14060649
Chicago/Turabian StyleBagatin, Freja, Ante Prpić, Jelena Škunca Herman, Ognjen Zrinšćak, Renata Iveković, and Zoran Vatavuk. 2024. "Correlation between Structural and Functional Changes in Patients with Raised Intraocular Pressure Due to Graves’ Orbitopathy" Diagnostics 14, no. 6: 649. https://doi.org/10.3390/diagnostics14060649