Next Article in Journal
Symmetry and Beauty in Plato
Next Article in Special Issue
Fluctuating Asymmetry: Methods, Theory, and Applications
Previous Article in Journal
Hartee Fock Symmetry Breaking Effects in La2CuO4: Hints for connecting the Mott and Slater Pictures and Pseudogap Prediction
Previous Article in Special Issue
Inverse Supersymmetry Breaking in S1 × R3
Article Menu

Article Versions

Export Article

Open AccessReview
Symmetry 2010, 2(2), 437-454; doi:10.3390/sym2020437

Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application

Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan
*
Author to whom correspondence should be addressed.
Received: 30 January 2010 / Revised: 4 March 2010 / Accepted: 4 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Feature Papers: Symmetry Concepts and Applications)
Download PDF [180 KB, uploaded 25 March 2010]   |  

Abstract

The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In this review, recent advances in the desymmetrization of symmetric dienes in the diastereotopic group differentiating reaction and its synthetic application are presented.
Keywords: desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nakahara, K.; Fujioka, H. Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application. Symmetry 2010, 2, 437-454.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Symmetry EISSN 2073-8994 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top