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Symmetry 2010, 2(2), 437-454; doi:10.3390/sym2020437
Review

Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application

 and
*
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan
* Author to whom correspondence should be addressed.
Received: 30 January 2010 / Revised: 4 March 2010 / Accepted: 4 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Feature Papers: Symmetry Concepts and Applications)
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Abstract

The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In this review, recent advances in the desymmetrization of symmetric dienes in the diastereotopic group differentiating reaction and its synthetic application are presented.
Keywords: desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Nakahara, K.; Fujioka, H. Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application. Symmetry 2010, 2, 437-454.

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