Symmetry 2010, 2(2), 437-454; doi:10.3390/sym2020437
Review

Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application

Received: 30 January 2010; in revised form: 4 March 2010 / Accepted: 4 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Feature Papers: Symmetry Concepts and Applications)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The desymmetrization of symmetric compounds is a useful approach to obtain chiral building blocks. Readily available precursors with a prochiral unit could be converted into complex molecules with multiple stereogenic centers in a single step. In this review, recent advances in the desymmetrization of symmetric dienes in the diastereotopic group differentiating reaction and its synthetic application are presented.
Keywords: desymmetrization; symmetric diene; chiral auxiliary; C2-symmetric diol; acetal
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MDPI and ACS Style

Nakahara, K.; Fujioka, H. Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application. Symmetry 2010, 2, 437-454.

AMA Style

Nakahara K, Fujioka H. Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application. Symmetry. 2010; 2(2):437-454.

Chicago/Turabian Style

Nakahara, Kenji; Fujioka, Hiromichi. 2010. "Diastereoselective Desymmetrization of Symmetric Dienes and its Synthetic Application." Symmetry 2, no. 2: 437-454.

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